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Open AccessArticle

Enhancement of Exercise Performance by 48 Hours, and 15-Day Supplementation with Mangiferin and Luteolin in Men

1
Department of Physical Education and Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, 35017 Las Palmas de Gran Canaria, Spain
2
Nektium Pharma, Las Mimosas 8, Agüimes, 35118 Las Palmas de Gran Canaria, Spain
3
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Alcalá, Ctra. Madrid-Barcelona, km 33,600, 28871 Alcalá de Henares Madrid, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(2), 344; https://doi.org/10.3390/nu11020344
Received: 7 January 2019 / Revised: 26 January 2019 / Accepted: 29 January 2019 / Published: 6 February 2019
(This article belongs to the Special Issue Nutrition and Exercise Metabolism)
The natural polyphenols mangiferin and luteolin have free radical-scavenging properties, induce the antioxidant gene program and down-regulate the expression of superoxide-producing enzymes. However, the effects of these two polyphenols on exercise capacity remains mostly unknown. To determine whether a combination of luteolin (peanut husk extract containing 95% luteolin, PHE) and mangiferin (mango leave extract (MLE), Zynamite®) at low (PHE: 50 mg/day; and 140 mg/day of MLE containing 100 mg of mangiferin; L) and high doses (PHE: 100 mg/day; MLE: 420 mg/day; H) may enhance exercise performance, twelve physically active men performed incremental exercise to exhaustion, followed by sprint and endurance exercise after 48 h (acute effects) and 15 days of supplementation (prolonged effects) with polyphenols or placebo, following a double-blind crossover design. During sprint exercise, mangiferin + luteolin supplementation enhanced exercise performance, facilitated muscle oxygen extraction, and improved brain oxygenation, without increasing the VO2. Compared to placebo, mangiferin + luteolin increased muscle O2 extraction during post-exercise ischemia, and improved sprint performance after ischemia-reperfusion likely by increasing glycolytic energy production, as reflected by higher blood lactate concentrations after the sprints. Similar responses were elicited by the two doses tested. In conclusion, acute and prolonged supplementation with mangiferin combined with luteolin enhances performance, muscle O2 extraction, and brain oxygenation during sprint exercise, at high and low doses. View Full-Text
Keywords: sports nutrition; ergogenic aids; polyphenols; performance; O2 extraction; ischemia; reperfusion; metabolism; exercise sports nutrition; ergogenic aids; polyphenols; performance; O2 extraction; ischemia; reperfusion; metabolism; exercise
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MDPI and ACS Style

Gelabert-Rebato, M.; Wiebe, J.C.; Martin-Rincon, M.; Galvan-Alvarez, V.; Curtelin, D.; Perez-Valera, M.; Juan Habib, J.; Pérez-López, A.; Vega, T.; Morales-Alamo, D.; Calbet, J.A.L. Enhancement of Exercise Performance by 48 Hours, and 15-Day Supplementation with Mangiferin and Luteolin in Men. Nutrients 2019, 11, 344.

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