Can Resveratrol Treatment Control the Progression of Induced Periodontal Disease? A Systematic Review and Meta-Analysis of Preclinical Studies

Institute of Agricultural Sciences, Universidade dos Vales do Jequitinhonha e Mucuri—UFVJM, Rua Vereador João Narciso, n.º 1380–Bairro Cachoeira, Unaí, Minas Gerais 38610-000, Brazil

Department of Veterinary Medicine, Universidade Federal de Lavras—UFLA, Mail Box 3037, Lavras, Minas Gerais 37200-000, Brazil

Department of Exact Sciences, Universidade Federal de Lavras—UFLA, Mail Box 3037, Lavras, Minas Gerais 37200-000, Brazil

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Department of Health Sciences, Universidade Federal de Lavras—UFLA, Mail Box 3037, Lavras, Minas Gerais 37200-000, Brazil

Author to whom correspondence should be addressed.

Nutrients 2019, 11(5), 953; https://doi.org/10.3390/nu11050953

Received: 7 March 2019 / Revised: 16 April 2019 / Accepted: 24 April 2019 / Published: 26 April 2019

(This article belongs to the Special Issue Resveratrol and Its Analogs in Human Diseases)

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Abstract

Resveratrol is an anti-inflammatory compound found in several foods. Periodontal disease (PD) is associated to other systemic diseases, and inflammation may be responsible for the association. Consequently, controlling inflammation not only may benefit oral health but also may assist with the management of other chronic inflammatory conditions. We aimed to investigate the effects of resveratrol administration on PD control in preclinical studies. A systematic search was performed for scientific articles using both electronic databases and a manual search using combinations of the following keywords: “resveratrol” OR “3,5,4′-trihydroxystilbene” AND “periodontal disease” OR “periodontitis” OR “gingivitis”. Only in vivo original studies investigating resveratrol treatment on experimental animal models of PD were selected. A quality assessment of the studies was performed using the Animal Research Reporting In Vivo Experiment (ARRIVE) guidelines, and the risk of bias was assessed using the Syrcle tool. The search returned 570 articles, and 11 matched the inclusion criteria. A meta-analysis showed that resveratrol treatment attenuated alveolar bone loss (τ² = 0.0041; 95% CI: −0.14; −0.04). The ARRIVE criteria reported a good quality of studies in general (mean score 28.5 ± 2.5). However, five Syrcle domains indicated a high risk of bias or did not present information clearly. We concluded that, in preclinical studies, resveratrol treatment prevented PD progression. View Full-Text

Keywords: 2,3,5,4′-tetrahydroxystilbene-2-O-β-glucoside; Periodontitis; Oral Health; Mouth Diseases; Functional Food

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MDPI and ACS Style

Andrade, E.F.; Orlando, D.R.; Araújo, A.M.S.; de Andrade, J.N.B.M.; Azzi, D.V.; de Lima, R.R.; Lobo-Júnior, A.R.; Pereira, L.J. Can Resveratrol Treatment Control the Progression of Induced Periodontal Disease? A Systematic Review and Meta-Analysis of Preclinical Studies. Nutrients 2019, 11, 953. https://doi.org/10.3390/nu11050953

AMA Style

Andrade EF, Orlando DR, Araújo AMS, de Andrade JNBM, Azzi DV, de Lima RR, Lobo-Júnior AR, Pereira LJ. Can Resveratrol Treatment Control the Progression of Induced Periodontal Disease? A Systematic Review and Meta-Analysis of Preclinical Studies. Nutrients. 2019; 11(5):953. https://doi.org/10.3390/nu11050953

Chicago/Turabian Style

Andrade, Eric F., Débora R. Orlando, Amanda M.S. Araújo, James N.B.M. de Andrade, Diana V. Azzi, Renato R. de Lima, Adalfredo R. Lobo-Júnior, and Luciano J. Pereira. 2019. "Can Resveratrol Treatment Control the Progression of Induced Periodontal Disease? A Systematic Review and Meta-Analysis of Preclinical Studies" Nutrients 11, no. 5: 953. https://doi.org/10.3390/nu11050953

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Can Resveratrol Treatment Control the Progression of Induced Periodontal Disease? A Systematic Review and Meta-Analysis of Preclinical Studies

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