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Open AccessArticle

Associations of AD Biomarkers and Cognitive Performance with Nutritional Status: The NUDAD Project

1
Department of Nutrition and Dietetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute, 1081HV Amsterdam, The Netherlands
2
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081HZ Amsterdam, The Netherlands
3
Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam and the Amsterdam Public Health Research Institute, 1081HV Amsterdam, The Netherlands
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Division of Human Nutrition and Health, Wageningen University & Research, 6708WE Wageningen, The Netherlands
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Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081HZ Amsterdam, The Netherlands
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FrieslandCampina, 3818LE Amersfoort, The Netherlands
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Department of Nutrition and Health, HAN University of Applied Sciences, 6525EJ Nijmegen, The Netherlands
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(5), 1161; https://doi.org/10.3390/nu11051161
Received: 9 May 2019 / Revised: 15 May 2019 / Accepted: 21 May 2019 / Published: 23 May 2019
As malnutrition is common in patients with Alzheimer’s disease (AD), we evaluated nutritional status and body composition of patients with AD, mild cognitive impairment (MCI) and controls, and studied associations of AD biomarkers and cognitive performance with nutritional status and body composition. We included 552 participants, of which 198 patients had AD, 135 patients had MCI and 219 controls. We assessed nutritional status (mini nutritional assessment (MNA)) and body composition (body mass index (BMI), fat-free mass (FFM) and waist circumference). Linear regression analyses (adjusted for age, gender and education where appropriate) were applied to test associations of AD biomarkers and cognitive performance on five domains with nutritional parameters (dependent). Patients with MCI and AD had a lower BMI and MNA score than controls. Worse performance in all cognitive domains was associated with lower MNA score, but not with body composition. AD biomarkers were associated with MNA score, BMI and waist circumference, and associations with MNA score remained after adjustment for cognitive performance. Both AD biomarkers and cognitive performance were associated with nutritional status, associations with AD biomarkers remained after adjustment for cognition. Our data suggest that malnutrition is not only related to impaired cognition but also to AD pathology. View Full-Text
Keywords: Alzheimer’s disease; mild cognitive impairment; subjective cognitive decline; malnutrition; older adults; body composition Alzheimer’s disease; mild cognitive impairment; subjective cognitive decline; malnutrition; older adults; body composition
MDPI and ACS Style

Doorduijn, A.S.; Visser, M.; van de Rest, O.; Kester, M.I.; de Leeuw, F.A.; Boesveldt, S.; Fieldhouse, J.L.P.; van den Heuvel, E.G.H.M.; Teunissen, C.E.; Scheltens, P.; van der Flier, W.M.; de van der Schueren, M.A.E. Associations of AD Biomarkers and Cognitive Performance with Nutritional Status: The NUDAD Project. Nutrients 2019, 11, 1161.

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