Next Article in Journal
Differences in Maternal Immunoglobulins within Mother’s Own Breast Milk and Donor Breast Milk and across Digestion in Preterm Infants
Next Article in Special Issue
Dietary Silicon and Its Impact on Plasma Silicon Levels in the Polish Population
Previous Article in Journal
Is Iron Supplementation Influenced by Sub-Clinical Inflammation?: A Randomized Controlled Trial Among Adolescent Schoolgirls in Myanmar
Previous Article in Special Issue
The Germ Fraction Inhibits Iron Bioavailability of Maize: Identification of an Approach to Enhance Maize Nutritional Quality via Processing and Breeding
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessArticle

Biotin Is Required for the Zinc Homeostasis in the Skin

Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(4), 919; https://doi.org/10.3390/nu11040919
Received: 30 March 2019 / Revised: 18 April 2019 / Accepted: 23 April 2019 / Published: 24 April 2019
(This article belongs to the Special Issue Dietary Trace Minerals)
  |  
PDF [1859 KB, uploaded 24 April 2019]
  |     |  

Abstract

Patients with biotin deficiency present symptoms that are similar to those in patients with acrodermatitis enteropathica (inherent zinc deficiency). However, the association between biotin and zinc deficiency remains unknown. We have previously shown that epidermal keratinocytes of mice fed zinc-deficient (ZD) diets secreted more adenosine triphosphate (ATP) than those of mice fed zinc-adequate (ZA) diets and that epidermal Langerhans cells are absent in ZD mice. Langerhans cells highly express CD39, which potently hydrolyzes ATP into adenosine monophosphate (AMP). Thus, a lack of Langerhans cells in ZD mice leads to non-hydrolysis of ATP, thereby leading to the development of ATP-mediated irritant contact dermatitis. In this study, we examined if biotin-deficient (BD) mice showed the same underlying mechanisms as those in ZD mice. BD mice showed reduced serum zinc levels, disappearance of epidermal Langerhans cells, and enhanced ATP production in the skin. Consequently, irritant contact dermatitis was significantly enhanced and prolonged in BD mice. In conclusion, the findings of our study showed that biotin deficiency leads to zinc deficiency because of which patients with biotin deficiency show similar symptoms as those with acrodermatitis enteropathica. View Full-Text
Keywords: biotin deficiency; zinc deficiency; acrodermatitis enteropathica; Langerhans cells; adenosine triphosphate biotin deficiency; zinc deficiency; acrodermatitis enteropathica; Langerhans cells; adenosine triphosphate
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Ogawa, Y.; Kinoshita, M.; Sato, T.; Shimada, S.; Kawamura, T. Biotin Is Required for the Zinc Homeostasis in the Skin. Nutrients 2019, 11, 919.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top