Rectal and Vaginal Eradication of Streptococcus agalactiae (GBS) in Pregnant Women by Using Lactobacillus salivarius CECT 9145, A Target-specific Probiotic Strain

Martín, Virginia; Cárdenas, Nivia; Ocaña, Sara; Marín, María; Arroyo, Rebeca; Beltrán, David; Badiola, Carlos; Fernández, Leónides; Rodríguez, Juan M.

doi:10.3390/nu11040810

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Rectal and Vaginal Eradication of Streptococcus agalactiae (GBS) in Pregnant Women by Using Lactobacillus salivarius CECT 9145, A Target-specific Probiotic Strain

^1,†,

^2,‡,

^2,3

¹,

¹,

⁴,

⁵,

and

^1,*

Department of Nutrition and Food Science, Complutense University of Madrid, 28040 Madrid, Spain

Department of Galenic Pharmacy and Food Technology, Complutense University of Madrid, 28040 Madrid, Spain

Unidad de Reproducción, Fundación Hospital Alcorcón, 28922 Alcorcón, Spain

⁴

Centro de Diagnóstico Médico, Ayuntamiento de Madrid, 28006 Madrid, Spain

⁵

Laboratorios Casen Recordati S.L., Vía de las Dos Castillas, 33, 28224 Pozuelo de Alarcón, Madrid, Spain

Author to whom correspondence should be addressed.

^†

Current address: Centro Nacional de Microbiología, Instituto de Salud Carlos III, Ctra. de Pozuelo, 28; 28222 Majadahonda, Madrid, Spain.

^‡

Current address: Probisearch S.L.U., C/ Santiago Grisolía, 2, 28760 Tres Cantos, Spain.

Nutrients 2019, 11(4), 810; https://doi.org/10.3390/nu11040810

Received: 13 March 2019 / Revised: 2 April 2019 / Accepted: 5 April 2019 / Published: 10 April 2019

(This article belongs to the Special Issue Nutraceutical, Nutrition Supplements and Human Health)

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Abstract

Streptococcus agalactiae (Group B Streptococci, GBS) can cause severe neonatal sepsis. The recto-vaginal GBS screening of pregnant women and intrapartum antibiotic prophylaxis (IAP) to positive ones is one of the main preventive options. However, such a strategy has some limitations and there is a need for alternative approaches. Initially, the vaginal microbiota of 30 non-pregnant and 24 pregnant women, including the assessment of GBS colonization, was studied. Among the Lactobacillus isolates, 10 Lactobacillus salivarius strains were selected for further characterization. In vitro characterization revealed that L. salivarius CECT 9145 was the best candidate for GBS eradication. Its efficacy to eradicate GBS from the intestinal and vaginal tracts of pregnant women was evaluated in a pilot trial involving 57 healthy pregnant women. All the volunteers in the probiotic group (n = 25) were GBS-positive and consumed ~9 log₁₀ cfu of L. salivarius CECT 9145 daily from week 26 to week 38. At the end of the trial (week 38), 72% and 68% of the women in this group were GBS-negative in the rectal and vaginal samples, respectively. L. salivarius CECT 9145 seems to be an efficient method to reduce the number of GBS-positive women during pregnancy, decreasing the number of women receiving IAP during delivery. View Full-Text

Keywords: Lactobacillus salivarius; Streptococcus agalactiae; GBS; probiotic; pregnancy

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MDPI and ACS Style

Martín, V.; Cárdenas, N.; Ocaña, S.; Marín, M.; Arroyo, R.; Beltrán, D.; Badiola, C.; Fernández, L.; Rodríguez, J.M. Rectal and Vaginal Eradication of Streptococcus agalactiae (GBS) in Pregnant Women by Using Lactobacillus salivarius CECT 9145, A Target-specific Probiotic Strain. Nutrients 2019, 11, 810. https://doi.org/10.3390/nu11040810

AMA Style

Martín V, Cárdenas N, Ocaña S, Marín M, Arroyo R, Beltrán D, Badiola C, Fernández L, Rodríguez JM. Rectal and Vaginal Eradication of Streptococcus agalactiae (GBS) in Pregnant Women by Using Lactobacillus salivarius CECT 9145, A Target-specific Probiotic Strain. Nutrients. 2019; 11(4):810. https://doi.org/10.3390/nu11040810

Chicago/Turabian Style

Martín, Virginia, Nivia Cárdenas, Sara Ocaña, María Marín, Rebeca Arroyo, David Beltrán, Carlos Badiola, Leónides Fernández, and Juan M. Rodríguez. 2019. "Rectal and Vaginal Eradication of Streptococcus agalactiae (GBS) in Pregnant Women by Using Lactobacillus salivarius CECT 9145, A Target-specific Probiotic Strain" Nutrients 11, no. 4: 810. https://doi.org/10.3390/nu11040810

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Rectal and Vaginal Eradication of Streptococcus agalactiae (GBS) in Pregnant Women by Using Lactobacillus salivarius CECT 9145, A Target-specific Probiotic Strain

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