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Open AccessReview

Saffron (Crocus sativus L.) in Ocular Diseases: A Narrative Review of the Existing Evidence from Clinical Studies

1
Aston University, School of Life and Health Sciences, Aston Triangle, Birmingham B4 7ET, UK
2
Aston Medical Research Institute, Aston Medical School, Aston University, Birmingham B4 7ET, UK
3
WISDEM, University Hospitals Coventry and Warwickshire NHS Trust, Coventry CV2 2DX, UK
4
Translational & Experimental Medicine, Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(3), 649; https://doi.org/10.3390/nu11030649
Received: 1 March 2019 / Revised: 10 March 2019 / Accepted: 13 March 2019 / Published: 18 March 2019
(This article belongs to the Special Issue Nutrition and Eye Health)
Saffron (Crocus sativus L.) and its main constituents, i.e., crocin and crocetin, are natural carotenoid compounds, which have been reported to possess a wide spectrum of properties and induce pleiotropic anti-inflammatory, anti-oxidative, and neuroprotective effects. An increasing number of experimental, animal, and human studies have investigated the effects and mechanistic pathways of these compounds in order to assess their potential therapeutic use in ocular diseases (e.g., in age related macular degeneration, glaucoma, and diabetic maculopathy). This narrative review presents the key findings of published clinical studies that examined the effects of saffron and/or its constituents in the context of ocular disease, as well as an overview of the proposed underlying mechanisms mediating these effects. View Full-Text
Keywords: saffron; Crocus Sativus L.; crocin; crocetin; supplements; anti-oxidant; anti-inflammatory; AMD; diabetes; glaucoma saffron; Crocus Sativus L.; crocin; crocetin; supplements; anti-oxidant; anti-inflammatory; AMD; diabetes; glaucoma
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MDPI and ACS Style

Heitmar, R.; Brown, J.; Kyrou, I. Saffron (Crocus sativus L.) in Ocular Diseases: A Narrative Review of the Existing Evidence from Clinical Studies. Nutrients 2019, 11, 649. https://doi.org/10.3390/nu11030649

AMA Style

Heitmar R, Brown J, Kyrou I. Saffron (Crocus sativus L.) in Ocular Diseases: A Narrative Review of the Existing Evidence from Clinical Studies. Nutrients. 2019; 11(3):649. https://doi.org/10.3390/nu11030649

Chicago/Turabian Style

Heitmar, Rebekka; Brown, James; Kyrou, Ioannis. 2019. "Saffron (Crocus sativus L.) in Ocular Diseases: A Narrative Review of the Existing Evidence from Clinical Studies" Nutrients 11, no. 3: 649. https://doi.org/10.3390/nu11030649

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