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Nutraceuticals for the Treatment of Diabetic Retinopathy

Department of Biology, University of Pisa, via San Zeno 31, 56127 Pisa, Italy
Interdepartmental Research Center Nutrafood “Nutraceuticals and Food for Health”, University of Pisa, 56124 Pisa, Italy
Author to whom correspondence should be addressed.
Nutrients 2019, 11(4), 771;
Received: 11 February 2019 / Revised: 19 March 2019 / Accepted: 28 March 2019 / Published: 2 April 2019
(This article belongs to the Special Issue Nutrition and Eye Health)
Diabetic retinopathy (DR) is one of the most common complications of diabetes mellitus and is characterized by degeneration of retinal neurons and neoangiogenesis, causing a severe threat to vision. Nowadays, the principal treatment options for DR are laser photocoagulation, vitreoretinal surgery, or intravitreal injection of drugs targeting vascular endothelial growth factor. However, these treatments only act at advanced stages of DR, have short term efficacy, and cause side effects. Treatment with nutraceuticals (foods providing medical or health benefits) at early stages of DR may represent a reasonable alternative to act upstream of the disease, preventing its progression. In particular, in vitro and in vivo studies have revealed that a variety of nutraceuticals have significant antioxidant and anti-inflammatory properties that may inhibit the early diabetes-driven molecular mechanisms that induce DR, reducing both the neural and vascular damage typical of DR. Although most studies are limited to animal models and there is the problem of low bioavailability for many nutraceuticals, the use of these compounds may represent a natural alternative method to standard DR treatments. View Full-Text
Keywords: retina; oxidative stress; inflammation; microvascular lesions; neoangiogenesis; polyphenols; flavonoids; carotenoids; saponins retina; oxidative stress; inflammation; microvascular lesions; neoangiogenesis; polyphenols; flavonoids; carotenoids; saponins
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Rossino, M.G.; Casini, G. Nutraceuticals for the Treatment of Diabetic Retinopathy. Nutrients 2019, 11, 771.

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