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Open AccessArticle

Prevention of Recurrent Acute Otitis Media in Children Through the Use of Lactobacillus salivarius PS7, a Target-Specific Probiotic Strain

1
Department of Nutrition and Food Science, Complutense University of Madrid, 28040 Madrid, Spain
2
Centro de Salud Bermeo, Tonpoi Kalea, s/n, 48370 Bermeo, Bizkaia, Spain
3
Centro de Salud Silvano, Av. de Machupichu, 58, 28043 Madrid, Spain
4
Laboratorios Casen Recordati S.L., Vía de las Dos Castillas, 33, 28224 Pozuelo de Alarcón, Madrid, Spain
*
Author to whom correspondence should be addressed.
Current address: Probisearch S.L.U., C/Santiago Grisolía, 2, 28760 Tres Cantos, Spain.
Current address: Centro Nacional de Microbiología, Instituto de Salud Carlos III, Ctra. de Pozuelo, 28, 28222 Majadahonda, Madrid, Spain.
§
Current address: Centro de Salud, Donibane Plaza, s/n, 48287 Ea, Bizkaia, Spain.
Nutrients 2019, 11(2), 376; https://doi.org/10.3390/nu11020376
Received: 8 January 2019 / Revised: 2 February 2019 / Accepted: 4 February 2019 / Published: 12 February 2019
(This article belongs to the Special Issue Nutraceutical, Nutrition Supplements and Human Health)
Acute otitis media (AOM) is one of the most common bacterial infections in children. Empiric antibiotherapy leads to increasing antimicrobial resistance rates among otopathogens and may impair the correct development of the microbiota in early life. In this context, probiotics seem to be an attractive approach for preventing recurrent AOM (rAOM) through the restoration of the middle ear and nasopharyngeal microbiota. The aim of this study was the selection of a probiotic strain (Lactobacillus salivarius PS7), specifically tailored for its antagonism against otopathogens. Since L. salivarius PS7 was safe and displayed a strong antimicrobial activity against otopathogens, its efficacy in preventing rAOM was assessed in a trial involving 61 children suffering from rAOM. Children consumed daily ~1 × 109 CFU of L. salivarius PS7, and the number of AOM episodes were registered and compared with that observed in the previous 6 and 12 months. The microbiota of samples collected from the external auditory canal samples was quantitatively and qualitatively assessed. The number of AOM episodes during the intervention period decreased significantly (84%) when compared to that reported during the 6 months period before the probiotic intervention. In conclusion, L. salivarius PS7 is a promising strain for the prevention of rAOM in infants and children. View Full-Text
Keywords: Lactobacillus salivarius; otitis; probiotic; bacteriocin; prevention Lactobacillus salivarius; otitis; probiotic; bacteriocin; prevention
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MDPI and ACS Style

Cárdenas, N.; Martín, V.; Arroyo, R.; López, M.; Carrera, M.; Badiola, C.; Jiménez, E.; Rodríguez, J.M. Prevention of Recurrent Acute Otitis Media in Children Through the Use of Lactobacillus salivarius PS7, a Target-Specific Probiotic Strain. Nutrients 2019, 11, 376. https://doi.org/10.3390/nu11020376

AMA Style

Cárdenas N, Martín V, Arroyo R, López M, Carrera M, Badiola C, Jiménez E, Rodríguez JM. Prevention of Recurrent Acute Otitis Media in Children Through the Use of Lactobacillus salivarius PS7, a Target-Specific Probiotic Strain. Nutrients. 2019; 11(2):376. https://doi.org/10.3390/nu11020376

Chicago/Turabian Style

Cárdenas, Nivia; Martín, Virginia; Arroyo, Rebeca; López, Mario; Carrera, Marta; Badiola, Carlos; Jiménez, Esther; Rodríguez, Juan M. 2019. "Prevention of Recurrent Acute Otitis Media in Children Through the Use of Lactobacillus salivarius PS7, a Target-Specific Probiotic Strain" Nutrients 11, no. 2: 376. https://doi.org/10.3390/nu11020376

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