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Article

Sugar Responses of Human Enterochromaffin Cells Depend on Gut Region, Sex, and Body Mass

1
College of Medicine and Public Health, Flinders University, Bedford Park SA 5042, Australia
2
Nutrition & Metabolism, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA 5000, Australia
3
Adelaide Medical School, The University of Adelaide, Adelaide SA 5005, Australia
4
Department of Surgery, Flinders Medical Centre, Bedford Park, SA 5042, Australia
5
NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, SA 5005, Australia
6
Cardiovascular, Metabolic, and Endocrine Diseases Research Unit, Pfizer Worldwide Research and Development, Cambridge, MA 02139, USA
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(2), 234; https://doi.org/10.3390/nu11020234
Received: 21 November 2018 / Revised: 15 December 2018 / Accepted: 14 January 2019 / Published: 22 January 2019
(This article belongs to the Special Issue Fructose and Glucose for Human Health)
Gut-derived serotonin (5-HT) is released from enterochromaffin (EC) cells in response to nutrient cues, and acts to slow gastric emptying and modulate gastric motility. Rodent studies also evidence a role for gut-derived 5-HT in the control of hepatic glucose production, lipolysis and thermogenesis, and in mediating diet-induced obesity. EC cell number and 5-HT content is increased in the small intestine of obese rodents and human, however, it is unknown whether EC cells respond directly to glucose in humans, and whether their capacity to release 5-HT is perturbed in obesity. We therefore investigated 5-HT release from human duodenal and colonic EC cells in response to glucose, sucrose, fructose and α-glucoside (αMG) in relation to body mass index (BMI). EC cells released 5-HT only in response to 100 and 300 mM glucose (duodenum) and 300 mM glucose (colon), independently of osmolarity. Duodenal, but not colonic, EC cells also released 5-HT in response to sucrose and αMG, but did not respond to fructose. 5-HT content was similar in all EC cells in males, and colonic EC cells in females, but 3 to 4-fold higher in duodenal EC cells from overweight females (p < 0.05 compared to lean, obese). Glucose-evoked 5-HT release was 3-fold higher in the duodenum of overweight females (p < 0.05, compared to obese), but absent here in overweight males. Our data demonstrate that primary human EC cells respond directly to dietary glucose cues, with regional differences in selectivity for other sugars. Augmented glucose-evoked 5-HT release from duodenal EC is a feature of overweight females, and may be an early determinant of obesity. View Full-Text
Keywords: serotonin; 5-hydroxytryptamine; 5-HT; glucose; enterochromaffin; obesity; duodenum; colon serotonin; 5-hydroxytryptamine; 5-HT; glucose; enterochromaffin; obesity; duodenum; colon
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MDPI and ACS Style

Lumsden, A.L.; Martin, A.M.; Sun, E.W.; Schober, G.; Isaacs, N.J.; Pezos, N.; Wattchow, D.A.; de Fontgalland, D.; Rabbitt, P.; Hollington, P.; Sposato, L.; Due, S.L.; Rayner, C.K.; Nguyen, N.Q.; Liou, A.P.; Jackson, V.M.; Young, R.L.; Keating, D.J. Sugar Responses of Human Enterochromaffin Cells Depend on Gut Region, Sex, and Body Mass. Nutrients 2019, 11, 234. https://doi.org/10.3390/nu11020234

AMA Style

Lumsden AL, Martin AM, Sun EW, Schober G, Isaacs NJ, Pezos N, Wattchow DA, de Fontgalland D, Rabbitt P, Hollington P, Sposato L, Due SL, Rayner CK, Nguyen NQ, Liou AP, Jackson VM, Young RL, Keating DJ. Sugar Responses of Human Enterochromaffin Cells Depend on Gut Region, Sex, and Body Mass. Nutrients. 2019; 11(2):234. https://doi.org/10.3390/nu11020234

Chicago/Turabian Style

Lumsden, Amanda L., Alyce M. Martin, Emily W. Sun, Gudrun Schober, Nicole J. Isaacs, Nektaria Pezos, David A. Wattchow, Dayan de Fontgalland, Philippa Rabbitt, Paul Hollington, Luigi Sposato, Steven L. Due, Christopher K. Rayner, Nam Q. Nguyen, Alice P. Liou, V. M. Jackson, Richard L. Young, and Damien J. Keating 2019. "Sugar Responses of Human Enterochromaffin Cells Depend on Gut Region, Sex, and Body Mass" Nutrients 11, no. 2: 234. https://doi.org/10.3390/nu11020234

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