Next Article in Journal
The Effect of Macronutrients on Reproductive Hormones in Overweight and Obese Men: A Pilot Study
Previous Article in Journal
Modifications of Own Mothers’ Milk Fortification Protocol Affect Early Plasma IGF-I and Ghrelin Levels in Preterm Infants. A Randomized Clinical Trial
Open AccessArticle

Study of the Inhibitory Effects of Enteral Nutrition Formula on Indomethacin-Induced Gastric Lesions in Mice

1
Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20 Shinmachi, Nishitokyo-shi, Tokyo 202-8585, Japan
2
Department of Pharmacy, Ogikubo Hospital, 3-1-24 Imagawa, Suginami-ku, Tokyo 167-0035, Japan
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(12), 3058; https://doi.org/10.3390/nu11123058
Received: 4 October 2019 / Revised: 6 December 2019 / Accepted: 9 December 2019 / Published: 14 December 2019
We investigated the effects of enteral nutrition formula on non-steroidal anti-inflammatory drug (NSAID)-induced gastric lesions in mice. Male ICR mice aged 7–9 weeks old were fasted, then orally given either purified water, Mermed® One, or 2-fold diluted Terumeal® 2.0α as enteral nutrition (25 or 50 mL/kg each). Indomethacin (IND) was orally administered at 20 mg/kg after 30 min, and the stomach was removed 6 h later and fixed in formalin. The number and area of lesions in the stomachs of the mice given enteral nutrition showed a significant, dose-dependent decrease compared to the purified water-treated group, and no significant difference was seen between the two enteral nutrition-treated groups. Comparable time courses of plasma IND concentrations suggest that enteral nutrition does not inhibit gastrointestinal absorption of IND. Our findings indicate that administering enteral nutrition could inhibit the onset of NSAID-induced gastric ulcers. View Full-Text
Keywords: non-steroidal anti-inflammatory drugs; enteral nutrition formula; gastric lesions non-steroidal anti-inflammatory drugs; enteral nutrition formula; gastric lesions
Show Figures

Figure 1

MDPI and ACS Style

Yoshimi, T.; Yamagishi, Y.; Kanegawa, I.; Suda, M.; Saiki, R.; Tanaka, K.-I.; Goda, H.; Kudo, T.; Ito, K. Study of the Inhibitory Effects of Enteral Nutrition Formula on Indomethacin-Induced Gastric Lesions in Mice. Nutrients 2019, 11, 3058.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop