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Circulating miRNAs as Biomarkers of Obesity and Obesity-Associated Comorbidities in Children and Adolescents: A Systematic Review

Institute for Innovation & Sustainable Development in Food Chain, Public University of Navarre, Jeronimo de Ayanz Building, Campus de Arrosadia, 31006 Pamplona, Spain
TECNALIA, Parque Tecnológico de Álava, Leonardo Da Vinci, 11, 01510 Miñano, Spain
Nutrition and Obesity Group, Department of Nutrition and Food Science, Public University of the Basque Country (UPV/EHU) and Lucio Lascaray Research Institute, 01006 Vitoria, Spain
CIBEROBN (Physiopathology of Obesity and Nutrition Network CB12/03/30038), Health Institute Carlos III (ISCIII), 28029 Madrid, Spain
Instituto de Investigación Sanitaria BIOARABA, 01006 Vitoria, Spain
Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology (INYTA), Biomedical Research Centre (CIBM), University of Granada, Avda. del Conocimiento s/n, 18016 Armilla, Spain
Instituto de Investigación Biosanitaria IBS.GRANADA, Complejo Hospitalario Universitario de Granada, 18014 Granada, Spain
Author to whom correspondence should be addressed.
Nutrients 2019, 11(12), 2890;
Received: 21 October 2019 / Revised: 11 November 2019 / Accepted: 25 November 2019 / Published: 27 November 2019
(This article belongs to the Special Issue Nutrition, microRNAs and Human Health)
Early detection of obesity and its associated comorbidities in children needs priority for the development of effective therapeutic intervention. Circulating miRNAs (microRNAs) have been proposed as biomarkers for obesity and its comorbidities; therefore, we conducted a systematic review to summarize results of studies that have quantified the profile of miRNAs in children and adolescents with obesity and/or associated disorders. Nine studies aiming to examine differences in miRNA expression levels between children with normal weight and obesity or between obese children with or without cardiometabolic diseases were included in this review. We identified four miRNAs overexpressed in obesity (miR-222, miR-142–3, miR-140-5p, and miR-143) and two miRNAs (miR-122 and miR-34a) overexpressed in children with obesity and nonalcoholic fatty liver disease (NAFLD) and/or insulin resistance. In conclusion, circulating miRNAs are promising diagnostic biomarkers of obesity-associated diseases such as NAFLD and type 2 diabetes already in childhood. However, more studies in children, using massive search technology and with larger sample sizes, are required to draw any firm conclusions. View Full-Text
Keywords: miRNAs; childhood obesity; biomarkers miRNAs; childhood obesity; biomarkers
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Oses, M.; Margareto Sanchez, J.; Portillo, M.P.; Aguilera, C.M.; Labayen, I. Circulating miRNAs as Biomarkers of Obesity and Obesity-Associated Comorbidities in Children and Adolescents: A Systematic Review. Nutrients 2019, 11, 2890.

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