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Open AccessArticle

Fragmented Dosing of β-alanine Induces A Body Weight-Independent Pharmacokinetic Response

Department of Movement & Sports Sciences, Ghent University, Ghent 9000, Belgium
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Nutrients 2019, 11(12), 2869; https://doi.org/10.3390/nu11122869
Received: 28 October 2019 / Revised: 13 November 2019 / Accepted: 19 November 2019 / Published: 23 November 2019
(This article belongs to the Special Issue Personalized Nutrition)
Personalised dosing of performance-enhancing food supplements is a hot topic. β-alanine is currently dosed using a fixed dose; however, evidence suggests that this might favour light compared to heavy subjects. A weight-relative dose seems to reverse this problem. In the present study, a novel dosing strategy was tested. A fragmented dose, composed of a fixed fragment of 800 mg and a weight-relative fragment of 10 mg/kg body weight, was compared to a fixed dose of 1600 mg and a weight-relative dose of 20 mg/kg body weight in a cohort of 20 subjects with a body weight ranging 48–139 kg (79.9 ± 24.4 kg). The results show that, following a fragmented dose, the influence of body weight on the pharmacokinetic response (iAUC) over a 210 min period was absent (r = −0.168; p = 0.478), in contrast to the fixed or weight-relative dose. The pharmacokinetic response also seemed more homogenous (CV% = 26%) following a fragmented dose compared to the fixed (33%) and the weight-relative dose (31%). The primary advantage of the easy-to-calculate fragmented dosing strategy is that it does not systematically favour or impair a certain weight group. Thorough dosage studies are lacking in the current field of sports and food supplements, therefore similar considerations can be made towards other (ergogenic) food supplements. View Full-Text
Keywords: food supplement; beta-alanine; carnosine; ergogenic; personalised nutrition food supplement; beta-alanine; carnosine; ergogenic; personalised nutrition
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Stautemas, J.; Van de Loock, A.; Van der Stede, T.; Pringels, L.; Derave, W. Fragmented Dosing of β-alanine Induces A Body Weight-Independent Pharmacokinetic Response. Nutrients 2019, 11, 2869.

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