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Is There a Contribution of Structural Brain Phenotypes to the Variance in Resting Energy Expenditure before and after Weight Loss in Overweight Females?

1
Institute of Human Nutrition and Food Science, Christian-Albrechts-University of Kiel, Düsternbrooker Weg 17-19, D-24105 Kiel, Germany
2
Division of Endocrinology, Diabetology and Clinical Nutrition, Department of Internal Medicine 1, University Hospital Schleswig-Holstein, Campus Kiel, University of Kiel, Düsternbrooker Weg 17-19, D-24105 Kiel, Germany
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(11), 2759; https://doi.org/10.3390/nu11112759
Received: 16 October 2019 / Revised: 10 November 2019 / Accepted: 11 November 2019 / Published: 14 November 2019
Brain gray (GM) and white matter (WM) are associated with resting energy expenditure (REE). The impact of weight loss on GM and WM masses, as well as on their associations with REE and the ratio between body and brain metabolism, i.e., encephalic measure (EM)), are unknown. Longitudinal data of 69 female Caucasian subjects (age range 19–69 years) with detailed information on fat mass (FM), fat free mas (FFM), GM, WM and REE. Mean weight loss was 14.5 ± 11.9 kg with changes in FM (−12.9 ± 9.8 kg), FFM (−1.7 ± 4.8 kg) and REE (−159 ± 191 kcal/24 h) (all p < 0.05). With weight loss, there were no changes in GM and WM. Before and after weight loss, FFM was the main determinant of REE (r2 = 0.483 and 0.413; p < 0.05). After weight loss, GM added to the variances in REE (3.6%), REEadjFFM (6.1%) and the REE on FFM residuals (6.6%). In addition, before and after weight loss GM explained 25.0% and 10.0% of the variances in EM (p < 0.05). Weight loss had no effect on volumes of GM and WM. After weight loss, both, GM added to the variances of REE, REE on FFM residuals and EM. View Full-Text
Keywords: weight loss; resting energy expenditure; brain; gray matter; white matter weight loss; resting energy expenditure; brain; gray matter; white matter
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Geisler, C.; Müller, M.J. Is There a Contribution of Structural Brain Phenotypes to the Variance in Resting Energy Expenditure before and after Weight Loss in Overweight Females? Nutrients 2019, 11, 2759.

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