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Open AccessArticle

Dietary Supplementation with Silicon-Enriched Spirulina Improves Arterial Remodeling and Function in Hypertensive Rats

1
PhyMedExp, Université de Montpellier, INSERM U1046, CNRS UMR9214, 34295 Montpellier, France
2
CNRS UMR 5305, Université Claude Bernard Lyon 1, 69367 Lyon, France
3
EA 7349 Université de Tours, 37200 Tours, France
4
Phyco-Biotech, 34070 Montpellier, France
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(11), 2574; https://doi.org/10.3390/nu11112574
Received: 14 August 2019 / Revised: 15 October 2019 / Accepted: 18 October 2019 / Published: 25 October 2019
(This article belongs to the Special Issue Diet and Vascular Function)
Vascular aging is characterized by increase in arterial stiffness and remodeling of the arterial wall with a loss of elastic properties. Silicon is an essential trace element highly present in arteries. It is involved in the constitution and stabilization of elastin fibers. The nutritional supply and bioavailability of silicon are often inadequate. Spirulina (Sp), micro algae have recognized nutritional properties and are able to incorporate minerals in a bioavailable form. We evaluated the effects of nutritional supplementation with silicon-enriched spirulina (SpSi) on arterial system structure and function in hypertension. Experiments were performed on hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats supplemented with SpSi or Sp over a period of three months. Arterial pressure, vascular function and morphometric parameters of thoracic aorta were analyzed. SpSi supplementation lowered arterial pressure in SHR and minimized morphometric alterations induced by hypertension. Aortic wall thickness and elastic fibers fragmentation were partially reversed. Collagen and elastin levels were increased in association with extracellular matrix degradation decrease. Vascular reactivity was improved with better contractile and vasorelaxant responses to various agonists. No changes were observed in SHR supplemented with Sp. The beneficial effects of SpSi supplementation evidenced here, may be attributable to Si enrichment and offer interesting opportunities to prevent cardiovascular risks. View Full-Text
Keywords: spirulina; silicon; hypertension; arterial structure; vascular function spirulina; silicon; hypertension; arterial structure; vascular function
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MDPI and ACS Style

Arthur-Ataam, J.; Bideaux, P.; Charrabi, A.; Sicard, P.; Fromy, B.; Liu, K.; Eddahibi, S.; Pasqualin, C.; Jouy, N.; Richard, S.; Virsolvy, A. Dietary Supplementation with Silicon-Enriched Spirulina Improves Arterial Remodeling and Function in Hypertensive Rats. Nutrients 2019, 11, 2574.

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