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Article

Similarities in Metabolic Flexibility and Hunger Hormone Ghrelin Exist between FTO Gene Variants in Response to an Acute Dietary Challenge

1
School of Science, College of Science, Engineering and Health, Royal Melbourne Institute of Technology (RMIT) University, Melbourne VIC 3083, Australia
2
Institute for Health and Sport, Victoria University, Melbourne VIC 3011, Australia
3
Department of Health and Medical Sciences, Faculty of Health, Arts and Design, Swinburne University of Technology, Melbourne VIC 3122, Australia
4
Australian Institute for Musculoskeletal Science (AIMSS), Western Health, Melbourne VIC 3021, Australia
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(10), 2518; https://doi.org/10.3390/nu11102518
Received: 6 September 2019 / Revised: 11 October 2019 / Accepted: 15 October 2019 / Published: 18 October 2019
(This article belongs to the Special Issue Precision Nutrition and Metabolic Disease)
The rs9939609 polymorphism of the fat mass and obesity-associated (FTO) gene has been associated with obesity, and studies have also shown that environmental/lifestyle interaction such as dietary intake might mediate this effect. The current study investigates the postprandial hormonal regulators of hunger and indirect markers of substrate utilisation and metabolic flexibility following a dietary challenge to determine if suppression of circulating ghrelin levels and/or reduced metabolic flexibility exist between FTO genotypes. One hundred and forty seven healthy, sedentary males and females (29.0 ± 0.7 yrs; 70.2 ± 1.1 kg; 169.1 ± 0.8 cm; 24.5 ± 0.3 kg/m2) complete a single experimental session. Anthropometric measures, circulating levels of active ghrelin, insulin and glucose, and substrate oxidation via indirect calorimetry, are measured pre-prandial and/or post-prandial. The FTO rs9939609 variant is genotyped using a real-time polymerase chain reaction. Metabolic flexibility (∆RER) is similar between FTO genotypes of the rs9939609 (T > A) polymorphism (p > 0.05). No differences in pre-prandial and/or postprandial substrate oxidation, plasma glucose, serum insulin or ghrelin are observed between genotypes (p > 0.05). These observations are independent of body mass index and gender. Altered postprandial responses in hunger hormones and metabolic flexibility may not be a mechanism by which FTO is associated with higher BMI and obesity in healthy, normal-weighted individuals. View Full-Text
Keywords: FTO; metabolic flexibility; oral glucose load FTO; metabolic flexibility; oral glucose load
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MDPI and ACS Style

Danaher, J.; Stathis, C.G.; Cooke, M.B. Similarities in Metabolic Flexibility and Hunger Hormone Ghrelin Exist between FTO Gene Variants in Response to an Acute Dietary Challenge. Nutrients 2019, 11, 2518. https://doi.org/10.3390/nu11102518

AMA Style

Danaher J, Stathis CG, Cooke MB. Similarities in Metabolic Flexibility and Hunger Hormone Ghrelin Exist between FTO Gene Variants in Response to an Acute Dietary Challenge. Nutrients. 2019; 11(10):2518. https://doi.org/10.3390/nu11102518

Chicago/Turabian Style

Danaher, Jessica, Christos G. Stathis, and Matthew B. Cooke. 2019. "Similarities in Metabolic Flexibility and Hunger Hormone Ghrelin Exist between FTO Gene Variants in Response to an Acute Dietary Challenge" Nutrients 11, no. 10: 2518. https://doi.org/10.3390/nu11102518

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