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Open AccessArticle

Hypnotic Effects of Lactobacillus fermentum PS150TM on Pentobarbital-Induced Sleep in Mice

Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 11221, Taiwan
Chung Mei Biopharma Co., Ltd., Taichung 40453, Taiwan
Bened Biomedical Co., Ltd., Taipei 11221, Taiwan
School of Chinese Medicine, China Medical University, Taichung 40402, Taiwan
Authors to whom correspondence should be addressed.
These authors contributed equally to this study.
Nutrients 2019, 11(10), 2409;
Received: 6 September 2019 / Revised: 1 October 2019 / Accepted: 5 October 2019 / Published: 9 October 2019
(This article belongs to the Special Issue Sleep, Nutrition, and Human Health)
The bidirectional communication between the gastrointestinal tract and the central nervous system appears to be functionally linked to the intestinal microbiome, namely the microbiome–gut–brain axis (MGBA). Probiotics with health benefits on psychiatric or neurological illnesses are generally called psychobiotics, and some of them may also be able to improve sleep by targeting the MGBA. This study aimed to investigate the effects of a psychobiotic strain, Lactobacillus fermentum PS150TM (PS150TM), on sleep improvement by using a pentobarbital-induced sleep mouse model. Compared with the vehicle control group, the oral administration of PS150TM, but not the other L. fermentum strains, significantly decreased the sleep latency and increased the sleep duration of mice, suggesting strain-specific sleep-improving effects of PS150TM. Moreover, the ingestion of diphenhydramine, an antihistamine used to treat insomnia, as a drug control group, only increased the sleep duration of mice. We also found that the sleep-improving effects of PS150TM are time- and dose-dependent. Furthermore, the oral administration of PS150TM could attenuate a caffeine-induced sleep disturbance in mice, and PS150TM appeared to increase the expression of the gene encoding the adenosine 1 receptor in the hypothalamus of mice, as assessed by quantitative real-time polymerase chain reaction. Taken together, our results present a potential application of PS150TM as a dietary supplement for sleep improvement. View Full-Text
Keywords: Lactobacillus fermentum; sleep; pentobarbital; caffeine; adenosine 1 receptor Lactobacillus fermentum; sleep; pentobarbital; caffeine; adenosine 1 receptor
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Lin, A.; Shih, C.-T.; Huang, C.-L.; Wu, C.-C.; Lin, C.-T.; Tsai, Y.-C. Hypnotic Effects of Lactobacillus fermentum PS150TM on Pentobarbital-Induced Sleep in Mice. Nutrients 2019, 11, 2409.

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