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Review

An Update on the Effects of Glyceollins on Human Health: Possible Anticancer Effects and Underlying Mechanisms

1
Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail)—UMR_S 1085, F-35000 Rennes, France
2
Laboratoire Nutrinov, Technopole Atalante Champeaux, 8 rue Jules Maillard de la Gournerie, 35012 Rennes Cedex, France
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(1), 79; https://doi.org/10.3390/nu11010079
Received: 29 November 2018 / Revised: 20 December 2018 / Accepted: 23 December 2018 / Published: 3 January 2019
(This article belongs to the Special Issue Phytochemicals in Health and Disease)
Biologically active plant-based compounds, commonly referred to as phytochemicals, can influence the expression and function of various receptors and transcription factors or signaling pathways that play vital roles in cellular functions and are then involved in human health and diseases. Thus, phytochemicals may have a great potential to prevent and treat chronic diseases. Glyceollins, a group of phytoalexins that are isolated from soybeans, have attracted attention because they exert numerous effects on human functions and diseases, notably anticancer effects. In this review, we have presented an update on the effects of glyceollins in relation to their potential beneficial roles in human health. Despite a growing number of studies suggesting that this new family of phytochemicals can be involved in critical cellular pathways, such as estrogen receptor, protein kinase, and lipid kinase signaling pathways, future investigations will be needed to better understand their molecular mechanisms and their specific significance in biomedical applications. View Full-Text
Keywords: glyceollins; phytochemicals; dietary compounds; signaling pathways; estrogen receptor; breast cancer; human health glyceollins; phytochemicals; dietary compounds; signaling pathways; estrogen receptor; breast cancer; human health
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MDPI and ACS Style

Pham, T.H.; Lecomte, S.; Efstathiou, T.; Ferriere, F.; Pakdel, F. An Update on the Effects of Glyceollins on Human Health: Possible Anticancer Effects and Underlying Mechanisms. Nutrients 2019, 11, 79. https://doi.org/10.3390/nu11010079

AMA Style

Pham TH, Lecomte S, Efstathiou T, Ferriere F, Pakdel F. An Update on the Effects of Glyceollins on Human Health: Possible Anticancer Effects and Underlying Mechanisms. Nutrients. 2019; 11(1):79. https://doi.org/10.3390/nu11010079

Chicago/Turabian Style

Pham, Thu H., Sylvain Lecomte, Theo Efstathiou, Francois Ferriere, and Farzad Pakdel. 2019. "An Update on the Effects of Glyceollins on Human Health: Possible Anticancer Effects and Underlying Mechanisms" Nutrients 11, no. 1: 79. https://doi.org/10.3390/nu11010079

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