Next Article in Journal
Glucose Response during the Night Is Suppressed by Wheat Albumin in Healthy Participants: A Randomized Controlled Trial
Next Article in Special Issue
Evidence that Nitric Oxide is Involved in the Blood Pressure Lowering Effect of the Peptide AVFQHNCQE in Spontaneously Hypertensive Rats
Previous Article in Journal
Letter to the Editor Re: Borschel M., et al. Comparison of Growth of Healthy Term Infants Fed Extensively Hydrolyzed Protein- and Amino Acid-Based Infant Formulas. Nutrients 2018, 10, 289
Previous Article in Special Issue
Synergistic Effects of Sanghuang–Danshen Bioactives on Arterial Stiffness in a Randomized Clinical Trial of Healthy Smokers: An Integrative Approach to in silico Network Analysis
Open AccessArticle

Influence of Ellagitannins Extracted by Pomegranate Fruit on Disulfide Isomerase PDIA3 Activity

Dipartimento di Scienze Biochimiche “A. Rossi Fanelli”, Università degli Studi di Roma “La Sapienza”, Piazzale A. Moro, 5-00185 Rome, Italy
Istituto Pasteur-Fondazione Cenci Bolognetti, 00161 Roma, Italy
Dipartimento di Chimica e Tecnologie del Farmaco, Università degli Studi di Roma “La Sapienza”, Piazzale Aldo Moro, 5-00185 Roma, Italy
Dipartimento di Farmacia, Università “G. d’Annunzio” di Chieti-Pescara, Via dei Vestini, 31-66100 Chieti, Italy
Authors to whom correspondence should be addressed.
Nutrients 2019, 11(1), 186;
Received: 27 December 2018 / Revised: 9 January 2019 / Accepted: 14 January 2019 / Published: 17 January 2019
(This article belongs to the Special Issue Dietary Bioactive Compounds and Human Health and Disease)
Pomegranate fruit is a functional food of high interest for human health due to its wide range of phytochemicals with antioxidant properties are implicated in the prevention of inflammation and cancer. Ellagitannins, such as punicalagin and ellagic acid, play a role as anti-atherogenic and neuroprotective molecules in the complex fighting against the degenerative diseases. The aim of this work was to evaluate the composition in punicalagins and ellagic acid of differently obtained extracts from whole fruit, peels and juices, prepared by squeezing or by centrifugation, of pomegranate belonging to different cultivars. Moreover, a wider phenolic fingerprint was also determined. The bioactivity of the extracts was tested on the redox activity of PDIA3 disulfide isomerase, an enzyme involved in the regulation of several cellular functions and associated with different diseases such as cancer, prion disorders, Alzheimer’s and Parkinson’s diseases. The results demonstrate that the different ratios between punicalagin and ellagic acid modulate the enzyme activity and other ellagitannins could interfere with this activity. View Full-Text
Keywords: pomegranate; punicalagin; ellagic acid; HPLC-DAD; PDIA3; redox activity pomegranate; punicalagin; ellagic acid; HPLC-DAD; PDIA3; redox activity
Show Figures

Graphical abstract

MDPI and ACS Style

Altieri, F.; Cairone, F.; Giamogante, F.; Carradori, S.; Locatelli, M.; Chichiarelli, S.; Cesa, S. Influence of Ellagitannins Extracted by Pomegranate Fruit on Disulfide Isomerase PDIA3 Activity. Nutrients 2019, 11, 186.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop