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Open AccessArticle

Influence of Ellagitannins Extracted by Pomegranate Fruit on Disulfide Isomerase PDIA3 Activity

1
Dipartimento di Scienze Biochimiche “A. Rossi Fanelli”, Università degli Studi di Roma “La Sapienza”, Piazzale A. Moro, 5-00185 Rome, Italy
2
Istituto Pasteur-Fondazione Cenci Bolognetti, 00161 Roma, Italy
3
Dipartimento di Chimica e Tecnologie del Farmaco, Università degli Studi di Roma “La Sapienza”, Piazzale Aldo Moro, 5-00185 Roma, Italy
4
Dipartimento di Farmacia, Università “G. d’Annunzio” di Chieti-Pescara, Via dei Vestini, 31-66100 Chieti, Italy
*
Authors to whom correspondence should be addressed.
Nutrients 2019, 11(1), 186; https://doi.org/10.3390/nu11010186
Received: 27 December 2018 / Revised: 9 January 2019 / Accepted: 14 January 2019 / Published: 17 January 2019
(This article belongs to the Special Issue Dietary Bioactive Compounds and Human Health and Disease)
Pomegranate fruit is a functional food of high interest for human health due to its wide range of phytochemicals with antioxidant properties are implicated in the prevention of inflammation and cancer. Ellagitannins, such as punicalagin and ellagic acid, play a role as anti-atherogenic and neuroprotective molecules in the complex fighting against the degenerative diseases. The aim of this work was to evaluate the composition in punicalagins and ellagic acid of differently obtained extracts from whole fruit, peels and juices, prepared by squeezing or by centrifugation, of pomegranate belonging to different cultivars. Moreover, a wider phenolic fingerprint was also determined. The bioactivity of the extracts was tested on the redox activity of PDIA3 disulfide isomerase, an enzyme involved in the regulation of several cellular functions and associated with different diseases such as cancer, prion disorders, Alzheimer’s and Parkinson’s diseases. The results demonstrate that the different ratios between punicalagin and ellagic acid modulate the enzyme activity and other ellagitannins could interfere with this activity. View Full-Text
Keywords: pomegranate; punicalagin; ellagic acid; HPLC-DAD; PDIA3; redox activity pomegranate; punicalagin; ellagic acid; HPLC-DAD; PDIA3; redox activity
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MDPI and ACS Style

Altieri, F.; Cairone, F.; Giamogante, F.; Carradori, S.; Locatelli, M.; Chichiarelli, S.; Cesa, S. Influence of Ellagitannins Extracted by Pomegranate Fruit on Disulfide Isomerase PDIA3 Activity. Nutrients 2019, 11, 186.

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