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Nutrients 2018, 10(6), 715; https://doi.org/10.3390/nu10060715

Modulation of Free Amino Acid Profile in Healthy Humans Administered with Mastiha Terpenes. An Open-Label Trial

1
Laboratory of Chemistry-Biochemistry and Physical Chemistry of Foods, Department of Dietetics and Nutritional Science, School of Health Science and Education, Harokopio University Athens, 17671 Athens, Greece
2
Department of Pharmacy, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia
3
Chios Mastic Gum Growers Association, 1 K. Monomachou St., 82100 Chios, Greece
*
Author to whom correspondence should be addressed.
Received: 27 April 2018 / Revised: 29 May 2018 / Accepted: 29 May 2018 / Published: 3 June 2018
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Abstract

We aimed to explore whether plasma-free amino acids are modified in response to terpenes administration in healthy humans. In this open-label, single-arm acute trial, seventeen healthy male volunteers were administered with a naturally occurring product of known terpenes—namely mastiha—after overnight fasting. Blood samples were collected at different time points before and after ingestion. We aimed at identifying and quantifying 60 free amino acids in plasma applying Gas Chromatography-Mass Spectrometry. A total of 24 free amino acids were quantified. Branched-chain valine significantly decreased 4 h post-ingestion, whereas proline decreased at 6 h and ornithine at 2 h, compared to 0 h. These novel findings demonstrate that free amino acids levels are modulated in response to terpenes intake in healthy subjects. View Full-Text
Keywords: plasma-free amino acids; terpenes; GC-MS metabolic analysis; uric acid plasma-free amino acids; terpenes; GC-MS metabolic analysis; uric acid
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Papada, E.; Torović, L.; Amerikanou, C.; Kalogeropoulos, N.; Smyrnioudis, I.; Kaliora, A.C. Modulation of Free Amino Acid Profile in Healthy Humans Administered with Mastiha Terpenes. An Open-Label Trial. Nutrients 2018, 10, 715.

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