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Nutrients 2018, 10(6), 681;

Protective Effect of Aplysin Supplementation on Intestinal Permeability and Microbiota in Rats Treated with Ethanol and Iron

Department of Human Nutrition, College of Public Health, Qingdao University, 38 Dengzhou Road, Qingdao 266021, China
Basic Medical College, Qingdao University of Medicine, 308 Ningxia Road, Qingdao 266071, China
Author to whom correspondence should be addressed.
Received: 24 April 2018 / Revised: 20 May 2018 / Accepted: 22 May 2018 / Published: 27 May 2018
(This article belongs to the Special Issue Nutrition Solutions for a Changing World)
PDF [4926 KB, uploaded 27 May 2018]


Aplysin, a kind of phytochemicals or phytonutrients, is purified from red alga Laurencia tristicha. The present study aims to investigate the influence of aplysin on changes of intestinal permeability and microbiota induced by excessive ethanol and iron. Thirty male rats were randomly divided into three groups (10/group): control group (normal saline); ethanol + iron group as EI treated with ethanol (8–12 mL/kg/day) and iron (1000 mg/kg) in diet; EI supplemented with aplysin (150 mg/kg/day) group as AEI; the trial lasts for 12 weeks. The result showed that levels of plasma endotoxin, fatty acid-binding protein 2, D-lactic acid, diamine oxidase were increased in rats in the EI group; and significantly decreased by 14%, 17%, 26%, 16%, respectively (p < 0.05) in the AEI group after the 12-week aplysin treatment. Moreover, in the AEI group the amount of Escherichia coli and Bacteroides fragilis were higher, while the amount of Lactobacillus, Bifidobacterium and Clostridium were lower than those in the EI group. The expressions of iron transporters divalent-metal transporter 1(DMT1) and ferroportin 1(FPN1) were significantly upregulated in the EI group compared to those in the control group. In conclusion, aplysin could effectively improve intestinal permeability and intestinal flora disorder induced with excessive ethanol and iron. View Full-Text
Keywords: ethanol; iron; aplysin; intestinal permeability; microbiota ethanol; iron; aplysin; intestinal permeability; microbiota

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Ma, Y.; Li, R.; Liu, Y.; Liu, M.; Liang, H. Protective Effect of Aplysin Supplementation on Intestinal Permeability and Microbiota in Rats Treated with Ethanol and Iron. Nutrients 2018, 10, 681.

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