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Nutrients 2018, 10(5), 537; https://doi.org/10.3390/nu10050537

Enteral Nutrition in the Management of Pediatric and Adult Crohn’s Disease

Max Rady College of Medicine, Department of Medicine, Section of Gastroenterology, University of Manitoba, St. Boniface Hospital, Winnipeg, MB R2H 2A6, Canada
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Received: 3 March 2018 / Revised: 17 April 2018 / Accepted: 24 April 2018 / Published: 26 April 2018
(This article belongs to the Special Issue Advances in Enteral Nutrition)
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Abstract

Genetic and environmental factors are thought to profoundly influence the pathophysiology of Crohn’s disease (CD). Changes in dietary and hygiene patterns affect the interactions between the immune system and environment. The gut microbiome is responsible for mediating host immune response with significant dysbiosis observed in individuals with CD. Diet therapy using exclusive enteral nutrition (EEN) has been studied as primary therapy for the management of CD. EEN may cultivate the presence of beneficial microbiota, improve bile acid metabolism, and decrease the number of dietary microparticles possibly influencing disease and immune activity. In this review, we will address the current evidence on EEN in the management of adult and pediatric CD. In adults, EEN appears to be moderately beneficial for the induction of remission of CD; however, its use is understudied and underutilized. Stronger evidence is in place to support the use of EEN in pediatric CD with the added benefit of nutrition support and steroid-sparing therapy during the growth phase. Overall, EEN is an established therapy in inducing CD remission in the pediatric population while its role as primary therapy of adult Crohn’s disease remains to be defined. View Full-Text
Keywords: enteral nutrition; Crohn’s disease; pediatric; microbiome; fistula; Crohn’s disease therapy enteral nutrition; Crohn’s disease; pediatric; microbiome; fistula; Crohn’s disease therapy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Hansen, T.; Duerksen, D.R. Enteral Nutrition in the Management of Pediatric and Adult Crohn’s Disease. Nutrients 2018, 10, 537.

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