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Open AccessArticle

Galacto-Oligosaccharide/Polidextrose Enriched Formula Protects against Respiratory Infections in Infants at High Risk of Atopy: A Randomized Clinical Trial

1
Unit of Pediatrics, Department of Translational Medical Science, University Federico II, Via Pansini 5, 80131 Naples, Italy
2
Bambino Gesù Children’s Hospital, Division of Metabolism, Piazza di Sant’Onofrio, 4, 00165 Rome, Italy
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Department of Women’s and Children’s Health, University of Padua, Via Giustiniani 3, 35128 Padua, Italy
4
Pedianet Network, 35128 Padua, Italy
5
Istituti Clinici Scientifici Maugeri SpA Benefit Corporation, Via S. Severino Boezio, 28, 27100 Pavia, Italy
6
Consorzio per Valutazioni Biologiche e Farmacologiche, Via Luigi Porta, 14, 27100 Pavia, Italy
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(3), 286; https://doi.org/10.3390/nu10030286
Received: 8 January 2018 / Revised: 20 February 2018 / Accepted: 24 February 2018 / Published: 1 March 2018
Background: Early nutrition affects the risk of atopy and infections through modifications of intestinal microbiota. The Prebiotics in the Prevention of Atopy (PIPA) study was a 24-month randomised, double-blind, placebo-controlled trial. It aimed to evaluate the effects of a galacto-oligosaccharide/polydextrose (GOS/PDX)-formula (PF) on atopic dermatitis (AD) and common infections in infants who were born to atopic parents and to investigate the relationship among early nutrition, gut microbiota and clinical outcomes. Methods: A total of 201 and 199 infants were randomized to receive a PF and standard formula (SF), respectively; 140 infants remained on exclusive breastfeeding (BF). Results: The cumulative incidence of AD and its intensity and duration were not statistically different among the three groups. The number of infants with at least one episode of respiratory infection (RI) and the mean number of episodes until 48 weeks of age were significantly lower in the PF group than in the SF group. The number of patients with recurrent RIs and incidence of wheezing lower RIs until 96 weeks were lower in the PF group than the SF group, but similar to the BF group. Bifidobacteria and Clostridium cluster I colonization increased over time in the PF group but decreased in the SF and BF groups. Bifidobacteria had a protective role in RIs, whereas Clostridium cluster I was associated with atopy protection. Conclusion: The early administration of PF protects against RIs and mediates a species-specific modulation of the intestinal microbiota. Trial registration: clinicaltrial.gov Identifier: NCT02116452. View Full-Text
Keywords: nutrition; microbiome; general practice; atopic dermatitis; respiratory infections; acute gastroenteritis; prebiotics nutrition; microbiome; general practice; atopic dermatitis; respiratory infections; acute gastroenteritis; prebiotics
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MDPI and ACS Style

Ranucci, G.; Buccigrossi, V.; Borgia, E.; Piacentini, D.; Visentin, F.; Cantarutti, L.; Baiardi, P.; Felisi, M.; Spagnuolo, M.I.; Zanconato, S.; Baraldi, E.; Giaquinto, C.; Guarino, A. Galacto-Oligosaccharide/Polidextrose Enriched Formula Protects against Respiratory Infections in Infants at High Risk of Atopy: A Randomized Clinical Trial. Nutrients 2018, 10, 286.

AMA Style

Ranucci G, Buccigrossi V, Borgia E, Piacentini D, Visentin F, Cantarutti L, Baiardi P, Felisi M, Spagnuolo MI, Zanconato S, Baraldi E, Giaquinto C, Guarino A. Galacto-Oligosaccharide/Polidextrose Enriched Formula Protects against Respiratory Infections in Infants at High Risk of Atopy: A Randomized Clinical Trial. Nutrients. 2018; 10(3):286.

Chicago/Turabian Style

Ranucci, Giusy; Buccigrossi, Vittoria; Borgia, Eleonora; Piacentini, Daniela; Visentin, Federica; Cantarutti, Luigi; Baiardi, Paola; Felisi, Mariagrazia; Spagnuolo, Maria I.; Zanconato, Stefania; Baraldi, Eugenio; Giaquinto, Carlo; Guarino, Alfredo. 2018. "Galacto-Oligosaccharide/Polidextrose Enriched Formula Protects against Respiratory Infections in Infants at High Risk of Atopy: A Randomized Clinical Trial" Nutrients 10, no. 3: 286.

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