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Article

Coffee Intake Decreases Risk of Postmenopausal Breast Cancer: A Dose-Response Meta-Analysis on Prospective Cohort Studies

1
The Research Centre on Public Health, University Milano-Bicocca, 20900 Monza, Italy
2
Department of International Health, FHML, CAPHRI, Maastricht University, 6229 Maastricht, The Netherlands
3
Department of Epidemiology and Population Studies, Jagiellonian University Medical College, 31008 Krakow, Poland
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Scientific Directorate, National Cancer Institute-IRCCS, 33081 Aviano, Italy
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Division of Anesthesia and Pain Medicine, Istituto Nazionale Tumori-IRCCS-“Fondazione G. Pascale”, 80131 Naples, Italy
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Department of Biology and Biotechnology (DBB) “L. Spallanzani”, University of Pavia, 27100 Pavia, Italy
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Department of Abdominal Oncology, National Cancer Institute, IRCCS-Foundation G. Pascale, 80131 Naples, Italy
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Department of Medical Oncology, National Cancer Institute-IRCCS, 33081 Aviano, Italy
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(2), 112; https://doi.org/10.3390/nu10020112
Received: 2 November 2017 / Revised: 16 January 2018 / Accepted: 18 January 2018 / Published: 23 January 2018
(This article belongs to the Special Issue Effects of Polyphenol-Rich Foods on Human Health)
Aim: A dose-response meta-analysis was conducted in order to summarize the evidence from prospective cohort studies regarding the association between coffee intake and breast cancer risk. Methods: A systematic search was performed in electronic databases up to March 2017 to identify relevant studies; risk estimates were retrieved from the studies and linear and non-linear dose-response analysis modelled by restricted cubic splines was conducted. A stratified and subgroup analysis by menopausal and estrogen/progesterone receptor (ER/PR) status, smoking status and body mass index (BMI) were performed in order to detect potential confounders. Results: A total of 21 prospective studies were selected either for dose-response, the highest versus lowest category of consumption or subgroup analysis. The dose-response analysis of 13 prospective studies showed no significant association between coffee consumption and breast cancer risk in the non-linear model. However, an inverse relationship has been found when the analysis was restricted to post-menopausal women. Consumption of four cups of coffee per day was associated with a 10% reduction in postmenopausal cancer risk (relative risk, RR 0.90; 95% confidence interval, CI 0.82 to 0.99). Subgroup analyses showed consistent results for all potential confounding factors examined. Conclusions: Findings from this meta-analysis may support the hypothesis that coffee consumption is associated with decreased risk of postmenopausal breast cancer. View Full-Text
Keywords: coffee; caffeine; breast cancer; receptor; postmenopausal; dose-response; meta-analysis coffee; caffeine; breast cancer; receptor; postmenopausal; dose-response; meta-analysis
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MDPI and ACS Style

Lafranconi, A.; Micek, A.; De Paoli, P.; Bimonte, S.; Rossi, P.; Quagliariello, V.; Berretta, M. Coffee Intake Decreases Risk of Postmenopausal Breast Cancer: A Dose-Response Meta-Analysis on Prospective Cohort Studies. Nutrients 2018, 10, 112. https://doi.org/10.3390/nu10020112

AMA Style

Lafranconi A, Micek A, De Paoli P, Bimonte S, Rossi P, Quagliariello V, Berretta M. Coffee Intake Decreases Risk of Postmenopausal Breast Cancer: A Dose-Response Meta-Analysis on Prospective Cohort Studies. Nutrients. 2018; 10(2):112. https://doi.org/10.3390/nu10020112

Chicago/Turabian Style

Lafranconi, Alessandra, Agnieszka Micek, Paolo De Paoli, Sabrina Bimonte, Paola Rossi, Vincenzo Quagliariello, and Massimiliano Berretta. 2018. "Coffee Intake Decreases Risk of Postmenopausal Breast Cancer: A Dose-Response Meta-Analysis on Prospective Cohort Studies" Nutrients 10, no. 2: 112. https://doi.org/10.3390/nu10020112

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