Salmon Fillet Intake Led to Higher Serum Triacylglycerol in Obese Zucker Fa/Fa Rats But Not in Normolipidemic Long-Evans Rats
Linn Anja Vikøren 1,2, Aslaug Drotningsvik 1
, Svein Are Mjøs 3,4, Gunnar Mellgren 5,6 and Oddrun Anita Gudbrandsen 1,*
, Svein Are Mjøs 3,4, Gunnar Mellgren 5,6 and Oddrun Anita Gudbrandsen 1,*
1
Dietary Protein Research Group, Department of Clinical Medicine, University of Bergen, 5020 Bergen, Norway
2
Department of Clinical Science, University of Bergen, Haukeland University Hospital, 5020 Bergen, Norway
3
Department of Chemistry, University of Bergen, P.O. Box 7803, 5020 Bergen, Norway
4
Nofima BioLab, P.O. Box 1425 Oasen, 5828 Bergen, Norway
5
Department of Clinical Science, KG Jebsen Center for Diabetes Research, University of Bergen, Haukeland University Hospital, 5021 Bergen, Norway
6
Hormone Laboratory, Haukeland University Hospital, 5021 Bergen, Norway
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(10), 1459; https://doi.org/10.3390/nu10101459
Received: 23 August 2018 / Revised: 20 September 2018 / Accepted: 1 October 2018 / Published: 8 October 2018
Abstract
The triacylglycerol lowering effect of fatty fish and fish oils is well recognized, however we recently showed that salmon intake resulted in higher serum triacylglycerol concentration in obese Zucker fa/fa rats. Since effects of salmon fillet have never before been studied in rats, the objective of this study was to compare effects of salmon intake on serum lipids in hyperlipidemic obese rats with normolipidemic lean rats. Zucker fa/fa rats and Long-Evans rats were fed diets with 25% protein from baked salmon fillet and 75% protein from casein, or casein as sole protein source (control group) for four weeks. Serum triacylglycerol concentration was higher, and cholesterol and apolipoproteinB-100 concentrations were lower in Zucker fa/fa rats fed Baked Salmon Diet compared to Zucker fa/fa rats fed Control Diet, with no differences in serum triacylglycerol, cholesterol and apolipoproteinB-100 between Long-Evans rats fed Baked Salmon Diet or Control Diet. Serum triacylglycerol fatty acid composition showed greater similarities to dietary fatty acids in Zucker fa/fa rats than in Long-Evans rats. To conclude, intake of baked salmon fillet resulted in higher serum triacylglycerol concentration and lower serum cholesterol concentration in hyperlipidemic obese Zucker fa/fa rats but did not affect serum lipids in normolipidemic lean Long-Evans rats. View Full-TextKeywords:
n-3 PUFA; salmon; fatty fish; apoB48; apoB100; triacylglycerols; phospholipids; fatty acids; Zucker fa/fa rat; Long-Evans rat
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Vikøren, L.A.; Drotningsvik, A.; Mjøs, S.A.; Mellgren, G.; Gudbrandsen, O.A. Salmon Fillet Intake Led to Higher Serum Triacylglycerol in Obese Zucker Fa/Fa Rats But Not in Normolipidemic Long-Evans Rats. Nutrients 2018, 10, 1459.
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