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Clinics and Practice
Volume 11
Issue 4
10.3390/clinpract11040107
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Article

Clinical Characteristics, Treatment, and Short-Term Outcome in Patients with Heart Failure and Cancer

by
Jędrzej Piotrowski
1,
Małgorzata Timler
2,
Remigiusz Kozłowski
3,
Arkadiusz Stasiak
4,
Joanna Stasiak
5,
Andrzej Bissinger
6,
Dariusz Timler
3,
Wojciech Timler
3,
Michał Marczak
2,
Roman Załuska
2,* and
Grzegorz Piotrowski
6,7
1
Medical Faculty, Medical University of Lodz, 90-419 Lodz, Poland
2
Department of Management and Logistics in Healthcare, Medical University of Lodz, 90-419 Lodz, Poland
3
Department of Emergency Medicine and Disaster Medicine, Medical University of Lodz, 92-212 Lodz, Poland
4
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB3 9BB, UK
5
Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 9BB, UK
6
Cardiooncology Department, Medical University of Lodz, 90-647 Lodz, Poland
7
Cardiology Department, Nicolaus Copernicus Memorial Hospital, 93-513 Lodz, Poland
*
Author to whom correspondence should be addressed.
Clin. Pract. 2021, 11(4), 933-941; https://doi.org/10.3390/clinpract11040107
Submission received: 29 September 2021 / Revised: 18 November 2021 / Accepted: 29 November 2021 / Published: 6 December 2021
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Abstract

(1) Our study aimed to look at the clinical characteristics, treatment and short-term outcomes of patients hospitalized due to heart failure with coexisting cancer. (2) Methods: Seventy one cancer (Ca) patients and a randomly selected 70 patients without Ca, hospitalized due to heart failure exacerbation in the same time period constituted the study group (Ca patient group) and controls (non-Ca group), respectively. Data on clinical characteristics were collected retrospectively for both groups. (3) Results: Cancer patients presented with a less advanced NYHA class, had more frequent HFpEF, a higher peak troponin T level, and smaller left atrium size, as compared with controls. The in-hospital deaths of Ca patients were associated with: a higher New York Heart Association (NYHA) class, lower HgB level, worse renal function, higher K and AST levels, presence of diabetes mellitus, and HFpEF. By multivariate logistic regression analysis, impaired renal function was the only independent predictor of in-hospital death in Ca patients (OR-1.15; CI 1.05; 1.27); p = 0.017). The following covariates entered the regression: NYHA class, HgB, GFR, K+, AST, diabetes mellitus t.2, and HFpEF. (4) Conclusions: The clinical picture and the course of heart failure in patients with and without cancer are different.
Keywords: cancer; heart failure; treatment; short-term outcome cancer; heart failure; treatment; short-term outcome

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MDPI and ACS Style

Piotrowski, J.; Timler, M.; Kozłowski, R.; Stasiak, A.; Stasiak, J.; Bissinger, A.; Timler, D.; Timler, W.; Marczak, M.; Załuska, R.; et al. Clinical Characteristics, Treatment, and Short-Term Outcome in Patients with Heart Failure and Cancer. Clin. Pract. 2021, 11, 933-941. https://doi.org/10.3390/clinpract11040107

AMA Style

Piotrowski J, Timler M, Kozłowski R, Stasiak A, Stasiak J, Bissinger A, Timler D, Timler W, Marczak M, Załuska R, et al. Clinical Characteristics, Treatment, and Short-Term Outcome in Patients with Heart Failure and Cancer. Clinics and Practice. 2021; 11(4):933-941. https://doi.org/10.3390/clinpract11040107

Chicago/Turabian Style

Piotrowski, Jędrzej, Małgorzata Timler, Remigiusz Kozłowski, Arkadiusz Stasiak, Joanna Stasiak, Andrzej Bissinger, Dariusz Timler, Wojciech Timler, Michał Marczak, Roman Załuska, and et al. 2021. "Clinical Characteristics, Treatment, and Short-Term Outcome in Patients with Heart Failure and Cancer" Clinics and Practice 11, no. 4: 933-941. https://doi.org/10.3390/clinpract11040107

APA Style

Piotrowski, J., Timler, M., Kozłowski, R., Stasiak, A., Stasiak, J., Bissinger, A., Timler, D., Timler, W., Marczak, M., Załuska, R., & Piotrowski, G. (2021). Clinical Characteristics, Treatment, and Short-Term Outcome in Patients with Heart Failure and Cancer. Clinics and Practice, 11(4), 933-941. https://doi.org/10.3390/clinpract11040107

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