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Hematology Reports, Volume 17, Issue 1

February 2025 - 9 articles

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Cover Story: Coagulation disorders are well documented yet underestimated complications in solid tumors, significantly contributing to patient morbidity and mortality. Coagulation disorders in cancers manifest as venous thromboembolism, arterial thromboembolism, thrombotic microangiopathies, and disseminated intravascular coagulation. The relationship between cancer and coagulopathy is bidirectional. Solid tumors can induce a hypercoagulable state by expressing tissue factor, releasing procoagulants, platelet dysfunction, and endothelial wall activation. Conversely, hypercoagulability contributes to tumor progression and metastasis. This article reviews the current understanding of coagulation disorders in solid tumors, their clinical implications, and the future directions. View this paper

Articles (9)

  • Article
  • Open Access
1,495 Views
13 Pages

Awareness and Attitude of the General Population Towards Inherited Hemoglobinopathies in the Premarital Screening Program in the Northern Region of Saudi Arabia

  • Mariah N. Hafiz,
  • Nida Suhail,
  • Zakariya M. S. Mohammed,
  • Husham O. Elzein,
  • Hibah A. Almasmoum,
  • Awad E. Abass,
  • Mohammed M. Jawad and
  • Saoussen Trabelsi

Background: Premarital screening (PMS) is a nationwide program that helps high-risk individuals make decisions to avoid genetic and sexually transmitted diseases from spreading to their spouse or future offspring. This study examined the knowledge an...

  • Review
  • Open Access
1,212 Views
11 Pages

Solid Tumors, Liquid Challenges: The Impact of Coagulation Disorders

  • Nidha Shapoo,
  • Noella Boma,
  • Shobhana Chaudhari and
  • Vladimir Gotlieb

Coagulation disorders are increasingly recognized as significant complications in patients with solid tumors, affecting morbidity and mortality outcomes. Solid tumors can provoke a hypercoagulable state through the release of pro-coagulant factors, e...

  • Case Report
  • Open Access
1,016 Views
8 Pages

Bosutinib-Induced Pleural Effusion—Class Effect and Cross-Intolerance to All Tyrosine Kinase Inhibitors

  • Nikhil Vojjala,
  • Hizqueel A. Sami,
  • Nikhil Kumar Kotla,
  • Supriya Peshin,
  • Kanika Goyal,
  • Soumya Kondaveety,
  • Rishab Rajendra Prabhu and
  • Geetha Krishnamoorthy

Introduction: Tyrosine kinase inhibitors (TKIs) serve as the backbone in the management of chronic myelogenous leukemia and Philadelphia-positive Acute lymphoblastic Leukemia (Ph+ve ALL). With the growing use of TKIs, there has been an increase in ad...

  • Article
  • Open Access
1 Citations
1,490 Views
17 Pages

Risk Factors for Impaired Glucose Metabolism in Transfusion-Dependent Patients with β-Thalassemia: A Single-Center Retrospective Observational Study

  • Theodora Maria Venou,
  • Filippos Kyriakidis,
  • Fani Barmpageorgopoulou,
  • Stamatia Theodoridou,
  • Athanasios Vyzantiadis,
  • Philippos Klonizakis,
  • Eleni Gavriilaki and
  • Efthymia Vlachaki

Background/Objectives: B-thalassemia is a genetic disorder that leads to reduced or absent β-globin chains, often resulting in endocrine abnormalities due to iron overload, chronic anemia, and hypoxia. This study investigates the prevalence and...

  • Article
  • Open Access
1,293 Views
13 Pages

The Role of Ferritin and Folate in Determining Stem Cell Collection for Autologous Stem Cell Transplant in Multiple Myeloma

  • Charles J. Weeks,
  • Mohammad Mian,
  • Michael Stokes,
  • Matthew Gold,
  • Anvay Shah,
  • Rohan Vuppala,
  • Katherine J. Kim,
  • Abigayle B. Simon,
  • Jorge Cortes and
  • Anand Jillela
  • + 1 author

Background: An autologous stem cell transplant (ASCT) is the standard of care for eligible patients with multiple myeloma (MM). However, the success of ASCT largely hinges on efficient mobilization; thus, a thorough analysis of factors that may affec...

  • Article
  • Open Access
1,293 Views
8 Pages

Background: Peripheral erythrophagocytosis appears to be a unique sign of acquired immune-mediated hemolytic anemia. It is said to be rare but its prevalence among patients with autoimmune hemolytic anemia has not been studied. Methods: In this retro...

  • Case Report
  • Open Access
929 Views
6 Pages

AntiCD30-Conjugated Antibody Plus Standard BEAM as Conditioning Regimen for Autologous Hematopoietic Stem Cell Transplantation in Systemic Anaplastic Large Cell Lymphoma

  • Panayotis Kaloyannidis,
  • Basmah Al-Charfli,
  • Biju George,
  • Charbel Khalil,
  • Nour Al-Moghrabi,
  • Samar Mustafa,
  • Dima Ibrahim,
  • Mohammed Alfar,
  • Firuz Ibrahim and
  • Bassam Odeh
  • + 2 authors

Background/objectives: The outcome of refractory/relapsed systemic Anaplastic Large Cell Lymphoma (R/R-sALCL), especially for anaplastic lymphoma kinase-1 (ALK-1)-negative disease, remains dismal even after autologous hematopoietic stem cell transpla...

  • Review
  • Open Access
5 Citations
2,310 Views
10 Pages

A quarter of a century ago, sickle cell disease (SCD) was mainly viewed as a typical genetic disease inherited as a classical Mendelian trait. Therefore, the main focus concerning SCD was on diagnosis, meaning, genotyping, and identification of homoz...

  • Case Report
  • Open Access
1,060 Views
9 Pages

Background: T-cell prolymphocytic leukemia (T-PLL) is a rare mature T-cell lymphoma that is usually associated with poor prognosis and short overall survival. Methods: We present a case of a 61-year-old woman presenting with T-PLL and the leukemic ce...