Hematology Reports, Volume 17, Issue 1
February 2025 - 9 articles
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Cover Story: Coagulation disorders are well documented yet underestimated complications in solid tumors, significantly contributing to patient morbidity and mortality. Coagulation disorders in cancers manifest as venous thromboembolism, arterial thromboembolism, thrombotic microangiopathies, and disseminated intravascular coagulation. The relationship between cancer and coagulopathy is bidirectional. Solid tumors can induce a hypercoagulable state by expressing tissue factor, releasing procoagulants, platelet dysfunction, and endothelial wall activation. Conversely, hypercoagulability contributes to tumor progression and metastasis. This article reviews the current understanding of coagulation disorders in solid tumors, their clinical implications, and the future directions. View this paper