Next Article in Journal
Metabolic and Anthropometric Influences on Nerve Conduction Parameters in Patients with Peripheral Neuropathy: A Retrospective Chart Analysis
Previous Article in Journal
SCN8A Encephalopathy: Case Report and Literature Review
Open AccessReview

Tumor-Treating Fields Therapy for Pediatric Brain Tumors

1
Department of Hematology/Oncology, Tokyo Metropolitan Children’s Medical Center, 2-8-29, Musashidai, Fuchu, Tokyo 183-8561, Japan
2
Clinical Research Support Center, Tokyo Metropolitan Children’s Medical Center, 2-8-29, Musashidai, Fuchu, Tokyo 183-8561, Japan
3
Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, 1397-1, Yamane, Hidaka, Saitama 350-1298, Japan
4
Department of Neuro-Oncology, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, Tokyo 157-8535, Japan
5
Department of Neurosurgery, Saitama Children’s Medical Center, 1-2, Shin-toshin, Chuo-ku, Saitama 330-8777, Japan
6
Department of Pediatric Hematology/Oncology, Osaka City General Hospital, 2-13-22, Miyakojima-hondori, Miyakojima-ku, Osaka 534-0021, Japan
7
Department of Neurosurgery, Tokyo Metropolitan Children’s Medical Center, 2-8-29, Musashidai, Fuchu, Tokyo 183-8561, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Filippo Tempia
Neurol. Int. 2021, 13(2), 151-165; https://doi.org/10.3390/neurolint13020015
Received: 10 February 2021 / Revised: 10 March 2021 / Accepted: 15 March 2021 / Published: 8 April 2021
Tumor-treating fields (TTFields) are alternating electric fields applied continuously to the brain by attaching two-pair arrays on the scalp. Although TTFields therapy has demonstrated efficacy against supratentorial glioblastoma (GBM) in adults, its safety and efficacy in children have not been confirmed. Despite differences in the genetic etiology of the adult and pediatric forms of GBM, both have certain clinical behaviors in common, allowing us to test TTFields therapy in pediatric GBM. Recently, several, pediatric case-series using TTFields therapy have been published, and a few, prospective, pediatric studies are ongoing. Because GBMs are extremely rare in pediatric patients, where they comprise a wide variety of genetic subtypes, these pediatric studies are feasibility studies targeting various types of malignant brain tumor. Although they are important for confirming the safety and feasibility of TTFields therapy in the pediatric population, confirming its efficacy against each type of pediatric brain tumor, including the GBM, is difficult. Our clinical research team, therefore, planned an investigator-initiated clinical trial targeting pediatric supratentorial GBMs (as in adults) with the aim of expanding regulatory approval of TTFields therapy for pediatric GBM treatment based on safety and exploratory efficacy data in combination with the accumulated evidence on adult GBMs. View Full-Text
Keywords: tumor-treating fields; TTFields; pediatric brain tumors; glioblastoma; clinical trial tumor-treating fields; TTFields; pediatric brain tumors; glioblastoma; clinical trial
Show Figures

Figure 1

MDPI and ACS Style

Makimoto, A.; Nishikawa, R.; Terashima, K.; Kurihara, J.; Fujisaki, H.; Ihara, S.; Morikawa, Y.; Yuza, Y. Tumor-Treating Fields Therapy for Pediatric Brain Tumors. Neurol. Int. 2021, 13, 151-165. https://doi.org/10.3390/neurolint13020015

AMA Style

Makimoto A, Nishikawa R, Terashima K, Kurihara J, Fujisaki H, Ihara S, Morikawa Y, Yuza Y. Tumor-Treating Fields Therapy for Pediatric Brain Tumors. Neurology International. 2021; 13(2):151-165. https://doi.org/10.3390/neurolint13020015

Chicago/Turabian Style

Makimoto, Atsushi; Nishikawa, Ryo; Terashima, Keita; Kurihara, Jun; Fujisaki, Hiroyuki; Ihara, Satoshi; Morikawa, Yoshihiko; Yuza, Yuki. 2021. "Tumor-Treating Fields Therapy for Pediatric Brain Tumors" Neurol. Int. 13, no. 2: 151-165. https://doi.org/10.3390/neurolint13020015

Find Other Styles

Article Access Map by Country/Region

1
Back to TopTop