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Cardiogenetics, Volume 13, Issue 1

2023 March - 5 articles

Cover Story: Arrhythmogenic cardiomyopathy (ACM) is an inherited multi-faceted cardiac disease that causes sudden cardiac death. Recent clinical studies have recognized that ventricular arrhythmias were the underlying cause of death in post-COVID-19 patients due to established systemic inflammation associated with viral myocarditis. Currently, the available therapeutic options for treating this disease are either pharmacological or non-pharmacological. The most commonly used option includes an implantable cardioverter defibrillator (ICD) that can prevent further life-threatening actions of fibrillation. However, one of the only other options is heart transplantation. Therefore, there is an imperative need to tackle all these forms of ACM, which might be possible due to genome editing technology. View this paper
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Articles (5)

  • Article
  • Open Access
3 Citations
4,891 Views
14 Pages
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Sex Differences in Fatty Acid Metabolism and Blood Pressure Response to Dietary Salt in Humans

  • Jeanne A. Ishimwe,
  • Jane F. Ferguson and
  • Annet Kirabo
Cardiogenetics2023, 13(1), 33-46;https://doi.org/10.3390/cardiogenetics13010005

3 March 2023

Salt sensitivity is a trait in which high dietary sodium (Na+) intake causes an increase in blood pressure (BP). We previously demonstrated that in the gut, elevated dietary Na+ causes dysbiosis. The mechanistic interplay between excess dietary Na+-i...

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  • Article
  • Open Access
8 Citations
6,433 Views
16 Pages
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Lower Circulating Cell-Free Mitochondrial DNA Is Associated with Heart Failure in Type 2 Diabetes Mellitus Patients

  • Tetiana A. Berezina,
  • Mykola P. Kopytsya,
  • Olga V. Petyunina,
  • Alexander A. Berezin,
  • Zeljko Obradovic,
  • Lukas Schmidbauer,
  • Michael Lichtenauer and
  • Alexander E. Berezin
Cardiogenetics2023, 13(1), 15-30;https://doi.org/10.3390/cardiogenetics13010003

7 February 2023

Cell-free nuclear (cf-nDNA) and mitochondrial (cf-mDNA) DNA are released from damaged cells in type 2 diabetes mellitus (T2DM) patients, contributing to adverse cardiac remodeling, vascular dysfunction, and inflammation. The purpose of this study was...

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  • Article
  • Open Access
3,521 Views
13 Pages
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Anti-Ischemic Effect of Leptin in the Isolated Rat Heart Subjected to Global Ischemia-Reperfusion: Role of Cardiac-Specific miRNAs

  • Ekaterina A. Polyakova,
  • Evgeny N. Mikhaylov,
  • Sarkis M. Minasian,
  • Mikhail M. Galagudza and
  • Evgeny V. Shlyakhto
Cardiogenetics2023, 13(1), 1-13;https://doi.org/10.3390/cardiogenetics13010001

4 January 2023

Background: Leptin is an obesity-associated adipokine that has been implicated in cardiac protection against ischemia-reperfusion injury (IRI). In this study, concentration-dependent effects of leptin on myocardial IRI were investigated in the isolat...

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