Next Article in Journal
Therapeutic Cancer Vaccination with Ex Vivo RNA-Transfected Dendritic Cells—An Update
Next Article in Special Issue
Long-Acting Paliperidone Parenteral Formulations Based on Polycaprolactone Nanoparticles; the Influence of Stabilizer and Chitosan on In Vitro Release, Protein Adsorption, and Cytotoxicity
Previous Article in Journal
Solubility, Antioxidation, and Oral Bioavailability Improvement of Mangiferin Microparticles Prepared Using the Supercritical Antisolvent Method
Previous Article in Special Issue
Hyaluronan Graft Copolymers Bearing Fatty-Acid Residues as Self-Assembling Nanoparticles for Olanzapine Delivery
Open AccessArticle

Treating Intracranial Abscesses in Rats with Stereotactic Injection of Biodegradable Vancomycin-Embedded Microparticles

1
Division of Neurosurgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, Taipei 11031, Taiwan
2
Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan
3
Department of Anesthesiology, Chiayi Chang Gung Memorial Hospital, Chiayi 61363, Taiwan
4
Department of Mechanical Engineering, Chang Gung University, Tao-Yuan 33302, Taiwan
5
Department of Thoracic and Cardiovascular Surgery, Linkou Chang Gung Memorial. Hospital, Taoyuan 33302, Taiwan
6
Department of Orthopedic Surgery, Chang Gung Memorial Hospital-Linkuo, Tao-Yuan 33305, Taiwan
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(2), 91; https://doi.org/10.3390/pharmaceutics12020091
Received: 13 December 2019 / Revised: 16 January 2020 / Accepted: 21 January 2020 / Published: 22 January 2020
Brain abscesses are emergent and life-threating despite advances in modern neurosurgical techniques and antibiotics. The present study explores the efficacy of vancomycin embedded to 50:50 poly(lactic-co-glycolide acid) (PLGA) microparticles in the treatment of brain abscess. The vancomycin embedded microparticles (VMPs) were stereotactically introduced into the cerebral parenchyma in Staphylococcus aureus bacteria- induced brain abscess-bearing rats. Experimental rats were divided into three groups: group A (n = 13; no treatment), group B (n = 14; daily vancomycin injection (5 mg intraperitoneally), and group C (n = 12; stereotactic introduction of VMPs into the abscess cavity). Group C exhibited no inflammatory response and significantly increased survival and reduced mean abscess volumes (p <0.001) at the eighth week, compared with other groups. Vancomycin delivery via a biodegradable PLGA vehicle can easily attain Area Under the Curve (AUC)/minimum inhibitory concentration (MIC) ratios of ≥400, and strengthens the therapeutic efficacy of antibiotics without provoking any potential toxicity. Biodegradable VMPs are a safe and sustainable drug delivery vehicle for the treatment of brain abscess. View Full-Text
Keywords: brain abscess; stereotactic; poly(lactide-co-glycolide acid); electrospraying; drug delivery; vancomycin brain abscess; stereotactic; poly(lactide-co-glycolide acid); electrospraying; drug delivery; vancomycin
Show Figures

Figure 1

MDPI and ACS Style

Tseng, Y.-Y.; Kao, C.-W.; Liu, K.-S.; Tang, Y.-L.; Liu, Y.-W.; Liu, S.-J. Treating Intracranial Abscesses in Rats with Stereotactic Injection of Biodegradable Vancomycin-Embedded Microparticles. Pharmaceutics 2020, 12, 91. https://doi.org/10.3390/pharmaceutics12020091

AMA Style

Tseng Y-Y, Kao C-W, Liu K-S, Tang Y-L, Liu Y-W, Liu S-J. Treating Intracranial Abscesses in Rats with Stereotactic Injection of Biodegradable Vancomycin-Embedded Microparticles. Pharmaceutics. 2020; 12(2):91. https://doi.org/10.3390/pharmaceutics12020091

Chicago/Turabian Style

Tseng, Yuan-Yun; Kao, Ching-Wei; Liu, Kuo-Sheng; Tang, Ya-Ling; Liu, Yen-Wei; Liu, Shih-Jung. 2020. "Treating Intracranial Abscesses in Rats with Stereotactic Injection of Biodegradable Vancomycin-Embedded Microparticles" Pharmaceutics 12, no. 2: 91. https://doi.org/10.3390/pharmaceutics12020091

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop