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Pharmaceutics
Volume 12
Issue 2
10.3390/pharmaceutics12020091
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Article

Treating Intracranial Abscesses in Rats with Stereotactic Injection of Biodegradable Vancomycin-Embedded Microparticles

by
Yuan-Yun Tseng
1,2,
Ching-Wei Kao
3,4,
Kuo-Sheng Liu
5,
Ya-Ling Tang
4,
Yen-Wei Liu
5 and
Shih-Jung Liu
4,6,*
1
Division of Neurosurgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, Taipei 11031, Taiwan
2
Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan
3
Department of Anesthesiology, Chiayi Chang Gung Memorial Hospital, Chiayi 61363, Taiwan
4
Department of Mechanical Engineering, Chang Gung University, Tao-Yuan 33302, Taiwan
5
Department of Thoracic and Cardiovascular Surgery, Linkou Chang Gung Memorial. Hospital, Taoyuan 33302, Taiwan
6
Department of Orthopedic Surgery, Chang Gung Memorial Hospital-Linkuo, Tao-Yuan 33305, Taiwan
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(2), 91; https://doi.org/10.3390/pharmaceutics12020091
Submission received: 13 December 2019 / Revised: 16 January 2020 / Accepted: 21 January 2020 / Published: 22 January 2020
(This article belongs to the Special Issue Physicochemical Properties of Polymeric Micro- and Nanoparticles as Drug Carriers)
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Abstract

Brain abscesses are emergent and life-threating despite advances in modern neurosurgical techniques and antibiotics. The present study explores the efficacy of vancomycin embedded to 50:50 poly(lactic-co-glycolide acid) (PLGA) microparticles in the treatment of brain abscess. The vancomycin embedded microparticles (VMPs) were stereotactically introduced into the cerebral parenchyma in Staphylococcus aureus bacteria- induced brain abscess-bearing rats. Experimental rats were divided into three groups: group A (n = 13; no treatment), group B (n = 14; daily vancomycin injection (5 mg intraperitoneally), and group C (n = 12; stereotactic introduction of VMPs into the abscess cavity). Group C exhibited no inflammatory response and significantly increased survival and reduced mean abscess volumes (p <0.001) at the eighth week, compared with other groups. Vancomycin delivery via a biodegradable PLGA vehicle can easily attain Area Under the Curve (AUC)/minimum inhibitory concentration (MIC) ratios of ≥400, and strengthens the therapeutic efficacy of antibiotics without provoking any potential toxicity. Biodegradable VMPs are a safe and sustainable drug delivery vehicle for the treatment of brain abscess.
Keywords: brain abscess; stereotactic; poly(lactide-co-glycolide acid); electrospraying; drug delivery; vancomycin brain abscess; stereotactic; poly(lactide-co-glycolide acid); electrospraying; drug delivery; vancomycin

Share and Cite

MDPI and ACS Style

Tseng, Y.-Y.; Kao, C.-W.; Liu, K.-S.; Tang, Y.-L.; Liu, Y.-W.; Liu, S.-J. Treating Intracranial Abscesses in Rats with Stereotactic Injection of Biodegradable Vancomycin-Embedded Microparticles. Pharmaceutics 2020, 12, 91. https://doi.org/10.3390/pharmaceutics12020091

AMA Style

Tseng Y-Y, Kao C-W, Liu K-S, Tang Y-L, Liu Y-W, Liu S-J. Treating Intracranial Abscesses in Rats with Stereotactic Injection of Biodegradable Vancomycin-Embedded Microparticles. Pharmaceutics. 2020; 12(2):91. https://doi.org/10.3390/pharmaceutics12020091

Chicago/Turabian Style

Tseng, Yuan-Yun, Ching-Wei Kao, Kuo-Sheng Liu, Ya-Ling Tang, Yen-Wei Liu, and Shih-Jung Liu. 2020. "Treating Intracranial Abscesses in Rats with Stereotactic Injection of Biodegradable Vancomycin-Embedded Microparticles" Pharmaceutics 12, no. 2: 91. https://doi.org/10.3390/pharmaceutics12020091

APA Style

Tseng, Y.-Y., Kao, C.-W., Liu, K.-S., Tang, Y.-L., Liu, Y.-W., & Liu, S.-J. (2020). Treating Intracranial Abscesses in Rats with Stereotactic Injection of Biodegradable Vancomycin-Embedded Microparticles. Pharmaceutics, 12(2), 91. https://doi.org/10.3390/pharmaceutics12020091

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