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Viruses 2015, 7(8), 4326-4351;

Translational Control of the HIV Unspliced Genomic RNA

Molecular and Cellular Virology Laboratory, Program of Virology, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 834100, Santiago, Chile
CIRI, International Center for Infectiology Research, Université de Lyon, Lyon 69007, France
Inserm, U1111, Lyon 69007, France
Ecole Normale Supérieure de Lyon, Lyon 69007, France
Université Lyon 1, Centre International de Recherche en Infectiologie, Lyon 69007, France
CNRS, UMR5308, Lyon 69007, France
Authors to whom correspondence should be addressed.
Academic Editor: David Boehr
Received: 18 May 2015 / Revised: 18 May 2015 / Accepted: 17 July 2015 / Published: 4 August 2015
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Post-transcriptional control in both HIV-1 and HIV-2 is a highly regulated process that commences in the nucleus of the host infected cell and finishes by the expression of viral proteins in the cytoplasm. Expression of the unspliced genomic RNA is particularly controlled at the level of RNA splicing, export, and translation. It appears increasingly obvious that all these steps are interconnected and they result in the building of a viral ribonucleoprotein complex (RNP) that must be efficiently translated in the cytosolic compartment. This review summarizes our knowledge about the genesis, localization, and expression of this viral RNP. View Full-Text
Keywords: HIV-1; Rev; nuclear export; DDX3; cap-dependent translation; IRES HIV-1; Rev; nuclear export; DDX3; cap-dependent translation; IRES

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Rojas-Araya, B.; Ohlmann, T.; Soto-Rifo, R. Translational Control of the HIV Unspliced Genomic RNA. Viruses 2015, 7, 4326-4351.

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