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Viruses 2015, 7(8), 4303-4325;

Papillomavirus Infectious Pathways: A Comparison of Systems

Department of Microbiology and Immunology, The Pennsylvania State University, 500 University Drive, Hershey, PA 17033, USA
Author to whom correspondence should be addressed.
Academic Editor: Joanna Parish
Received: 6 June 2015 / Revised: 6 June 2015 / Accepted: 23 July 2015 / Published: 4 August 2015
(This article belongs to the Special Issue Tumour Viruses)
PDF [826 KB, uploaded 4 August 2015]


The HPV viral lifecycle is tightly linked to the host cell differentiation, causing difficulty in growing virions in culture. A system that bypasses the need for differentiating epithelium has allowed for generation of recombinant particles, such as virus-like particles (VLPs), pseudovirions (PsV), and quasivirions (QV). Much of the research looking at the HPV life cycle, infectivity, and structure has been generated utilizing recombinant particles. While recombinant particles have proven to be invaluable, allowing for a rapid progression of the HPV field, there are some significant differences between recombinant particles and native virions and very few comparative studies using native virions to confirm results are done. This review serves to address the conflicting data in the HPV field regarding native virions and recombinant particles. View Full-Text
Keywords: human papillomavirus (HPV); virus; native virions (NV); virus-like particles (VLPs); pseudovirions (PsV); quasivirions (QV) human papillomavirus (HPV); virus; native virions (NV); virus-like particles (VLPs); pseudovirions (PsV); quasivirions (QV)

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Biryukov, J.; Meyers, C. Papillomavirus Infectious Pathways: A Comparison of Systems. Viruses 2015, 7, 4303-4325.

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