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Viruses 2015, 7(8), 4385-4413;

The Virus-Host Interplay: Biogenesis of +RNA Replication Complexes

Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2E1, Canada
Department of Cell Biology, University of Alberta, Edmonton, AB T6G 2H7, Canada
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: David Boehr
Received: 16 June 2015 / Revised: 21 July 2015 / Accepted: 24 July 2015 / Published: 6 August 2015
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Positive-strand RNA (+RNA) viruses are an important group of human and animal pathogens that have significant global health and economic impacts. Notable members include West Nile virus, Dengue virus, Chikungunya, Severe acute respiratory syndrome (SARS) Coronavirus and enteroviruses of the Picornaviridae family.Unfortunately, prophylactic and therapeutic treatments against these pathogens are limited. +RNA viruses have limited coding capacity and thus rely extensively on host factors for successful infection and propagation. A common feature among these viruses is their ability to dramatically modify cellular membranes to serve as platforms for genome replication and assembly of new virions. These viral replication complexes (VRCs) serve two main functions: To increase replication efficiency by concentrating critical factors and to protect the viral genome from host anti-viral systems. This review summarizes current knowledge of critical host factors recruited to or demonstrated to be involved in the biogenesis and stabilization of +RNA virus VRCs. View Full-Text
Keywords: +RNA viruses; replication complexes; host factors; membranes +RNA viruses; replication complexes; host factors; membranes

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Reid, C.R.; Airo, A.M.; Hobman, T.C. The Virus-Host Interplay: Biogenesis of +RNA Replication Complexes. Viruses 2015, 7, 4385-4413.

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