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A Taxonomic Review of Clostridium difficile Phages and Proposal of a Novel Genus, “Phimmp04likevirus”

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Department of Infection, Immunity and Inflammation, University of Leicester, Leicestershire LE1 9HN, UK
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Department of Ecology and Evolutionary Biology, University of Arizona, AZ 85721, USA
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Author to whom correspondence should be addressed.
Academic Editor: Rob Lavigne
Viruses 2015, 7(5), 2534-2541; https://doi.org/10.3390/v7052534
Received: 16 March 2015 / Accepted: 13 May 2015 / Published: 21 May 2015
(This article belongs to the Section Bacterial Viruses)
Currently, only three phages that infect the medically important bacterium Clostridium difficile have been discussed by the International Committee of Viral Taxonomy (ICTV). They are all myoviruses, and have been assigned to the genus “phicd119likevirus”. An additional nine phages have since been described in the literature with their genome data available. The Phicd119likevirus is named after the type species: the myovirus ΦCD119 which was the first C. difficile phage to be sequenced. The two additional myoviruses, ϕCD27 and φC2, also fall into this genus based on the similarity of their genome and morphological characteristics. The other nine phages have not been assigned to this genus, and four of them do not fit the criteria for the current taxonomic grouping. We have applied protein clustering analysis to determine their phylogenetic relationships. From these results we propose an additional myoviridae genus, that we term “phiMMP04likevirus”. View Full-Text
Keywords: bacteriophage; Clostridium difficile; taxonomy; protein clustering; Siphoviridae; Myoviridae; small myovirus; bacteriophage phylogeny bacteriophage; Clostridium difficile; taxonomy; protein clustering; Siphoviridae; Myoviridae; small myovirus; bacteriophage phylogeny
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Hargreaves, K.R.; Clokie, M.R.J. A Taxonomic Review of Clostridium difficile Phages and Proposal of a Novel Genus, “Phimmp04likevirus”. Viruses 2015, 7, 2534-2541.

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