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Vascular Endothelial Growth Factor Levels in Dobrava/Belgrade Virus Infections

Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece
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Viruses 2013, 5(12), 3109-3118; https://doi.org/10.3390/v5123109
Received: 16 October 2013 / Revised: 2 December 2013 / Accepted: 3 December 2013 / Published: 10 December 2013
(This article belongs to the Special Issue Hantaviruses)
The levels of vascular endothelial growth factor-A (VEGF) were estimated in 102 serum samples from 63 hospitalized Greek patients with hemorrhagic fever with renal syndrome (HFRS) caused by Dobrava/Belgrade virus. Significantly higher VEGF levels were seen in the severe when compared with non-severe cases (mean values 851.96 pg/mL and 326.75 pg/mL, respectively; p = 0.003), while a significant difference was observed among groups based on the day after the onset of illness. In both severe and non-severe cases, VEGF peaked in the second week of illness; however, elevation of VEGF in the severe cases started later and remained high until convalescence, suggesting that the role of VEGF was associated with repair of vascular damage rather than with increased permeability. View Full-Text
Keywords: vascular endothelial growth factor; Dobrava/Belgrade virus; hemorrhagic fever with renal syndrome; hantavirus; Greece vascular endothelial growth factor; Dobrava/Belgrade virus; hemorrhagic fever with renal syndrome; hantavirus; Greece
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Tsergouli, K.; Papa, A. Vascular Endothelial Growth Factor Levels in Dobrava/Belgrade Virus Infections. Viruses 2013, 5, 3109-3118.

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