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Vascular Endothelial Growth Factor Levels in Dobrava/Belgrade Virus Infections
Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece
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Received: 16 October 2013; in revised form: 2 December 2013 / Accepted: 3 December 2013 / Published: 10 December 2013
Abstract: The levels of vascular endothelial growth factor-A (VEGF) were estimated in 102 serum samples from 63 hospitalized Greek patients with hemorrhagic fever with renal syndrome (HFRS) caused by Dobrava/Belgrade virus. Significantly higher VEGF levels were seen in the severe when compared with non-severe cases (mean values 851.96 pg/mL and 326.75 pg/mL, respectively; p = 0.003), while a significant difference was observed among groups based on the day after the onset of illness. In both severe and non-severe cases, VEGF peaked in the second week of illness; however, elevation of VEGF in the severe cases started later and remained high until convalescence, suggesting that the role of VEGF was associated with repair of vascular damage rather than with increased permeability.
Keywords: vascular endothelial growth factor; Dobrava/Belgrade virus; hemorrhagic fever with renal syndrome; hantavirus; Greece
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Tsergouli, K.; Papa, A. Vascular Endothelial Growth Factor Levels in Dobrava/Belgrade Virus Infections. Viruses 2013, 5, 3109-3118.
Tsergouli K, Papa A. Vascular Endothelial Growth Factor Levels in Dobrava/Belgrade Virus Infections. Viruses. 2013; 5(12):3109-3118.
Tsergouli, Katerina; Papa, Anna. 2013. "Vascular Endothelial Growth Factor Levels in Dobrava/Belgrade Virus Infections." Viruses 5, no. 12: 3109-3118.