Next Article in Journal
Investigating the Potential Shared Molecular Mechanisms between COVID-19 and Alzheimer’s Disease via Transcriptomic Analysis
Next Article in Special Issue
High-Density Lipoprotein Particles and Torque Teno Virus in Stable Outpatient Kidney Transplant Recipients
Previous Article in Journal
Urine: A Pitfall for Molecular Detection of Toscana Virus? An Analytical Proof-of-Concept Study
Previous Article in Special Issue
Smoking, Alcohol Intake and Torque Teno Virus in Stable Kidney Transplant Recipients
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Viruses
Volume 16
Issue 1
10.3390/v16010099
viruses-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

The Impact of First-Time SARS-CoV-2 Infection on Human Anelloviruses

by
Anne L. Timmerman
1,2,
Lisanne Commandeur
1,2,
Martin Deijs
1,2,
Maarten G. J. M. Burggraaff
1,2,
A. H. Ayesha Lavell
2,3,
Karlijn van der Straten
1,2,4,
Khadija Tejjani
1,2,
Jacqueline van Rijswijk
1,2,
Marit J. van Gils
1,2,
Jonne J. Sikkens
2,3,
Marije K. Bomers
2,3 and
Lia van der Hoek
1,2,*
1
Laboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
2
Amsterdam Institute for Infection and Immunity, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
3
Department of Internal Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
4
Department of Internal Medicine, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
*
Author to whom correspondence should be addressed.
Viruses 2024, 16(1), 99; https://doi.org/10.3390/v16010099
Submission received: 14 December 2023 / Revised: 4 January 2024 / Accepted: 5 January 2024 / Published: 9 January 2024
(This article belongs to the Special Issue Advancing Research of Anelloviruses)
Browse Figures
Versions Notes

Abstract

Members of the Anelloviridae family dominate the blood virome, emerging early in life. The anellome, representing the variety of anelloviruses within an individual, stabilizes by adulthood. Despite their supposedly commensal nature, elevated anellovirus concentrations under immunosuppressive treatment indicate an equilibrium controlled by immunity. Here, we investigated whether anelloviruses are sensitive to the immune activation that accompanies a secondary infection. As a model, we investigated 19 health care workers (HCWs) with initial SARS-CoV-2 infection, with blood sampling performed pre and post infection every 4 weeks in a 3-month-follow-up during the early 2020 COVID-19 pandemic. A concurrently followed control group (n = 27) remained SARS-CoV-2-negative. Serum anellovirus loads were measured using qPCR. A significant decrease in anellovirus load was found in the first weeks after SARS-CoV-2 infection, whereas anellovirus concentrations remained stable in the uninfected control group. A restored anellovirus load was seen approximately 10 weeks after SARS-CoV-2 infection. For five subjects, an in-time anellome analysis via Illumina sequencing could be performed. In three of the five HCWs, the anellome visibly changed during SARS-CoV-2 infection and returned to baseline in two of these cases. In conclusion, anellovirus loads in blood can temporarily decrease upon an acute secondary infection.
Keywords: TTV; TTMV; TTMDV; anellome; SARS-CoV-2; virome TTV; TTMV; TTMDV; anellome; SARS-CoV-2; virome

Share and Cite

MDPI and ACS Style

Timmerman, A.L.; Commandeur, L.; Deijs, M.; Burggraaff, M.G.J.M.; Lavell, A.H.A.; van der Straten, K.; Tejjani, K.; van Rijswijk, J.; van Gils, M.J.; Sikkens, J.J.; et al. The Impact of First-Time SARS-CoV-2 Infection on Human Anelloviruses. Viruses 2024, 16, 99. https://doi.org/10.3390/v16010099

AMA Style

Timmerman AL, Commandeur L, Deijs M, Burggraaff MGJM, Lavell AHA, van der Straten K, Tejjani K, van Rijswijk J, van Gils MJ, Sikkens JJ, et al. The Impact of First-Time SARS-CoV-2 Infection on Human Anelloviruses. Viruses. 2024; 16(1):99. https://doi.org/10.3390/v16010099

Chicago/Turabian Style

Timmerman, Anne L., Lisanne Commandeur, Martin Deijs, Maarten G. J. M. Burggraaff, A. H. Ayesha Lavell, Karlijn van der Straten, Khadija Tejjani, Jacqueline van Rijswijk, Marit J. van Gils, Jonne J. Sikkens, and et al. 2024. "The Impact of First-Time SARS-CoV-2 Infection on Human Anelloviruses" Viruses 16, no. 1: 99. https://doi.org/10.3390/v16010099

APA Style

Timmerman, A. L., Commandeur, L., Deijs, M., Burggraaff, M. G. J. M., Lavell, A. H. A., van der Straten, K., Tejjani, K., van Rijswijk, J., van Gils, M. J., Sikkens, J. J., Bomers, M. K., & van der Hoek, L. (2024). The Impact of First-Time SARS-CoV-2 Infection on Human Anelloviruses. Viruses, 16(1), 99. https://doi.org/10.3390/v16010099

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop