Nucleocapsid Structure of Negative Strand RNA Virus
Department of Chemistry, Georgia State University, Atlanta, GA 30302, USA
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Author to whom correspondence should be addressed.
Viruses 2020, 12(8), 835; https://doi.org/10.3390/v12080835
Received: 6 July 2020
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Revised: 23 July 2020
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Accepted: 27 July 2020
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Published: 30 July 2020
(This article belongs to the Special Issue In Memory of Michael Rossmann)
Negative strand RNA viruses (NSVs) include many important human pathogens, such as influenza virus, Ebola virus, and rabies virus. One of the unique characteristics that NSVs share is the assembly of the nucleocapsid and its role in viral RNA synthesis. In NSVs, the single strand RNA genome is encapsidated in the linear nucleocapsid throughout the viral replication cycle. Subunits of the nucleocapsid protein are parallelly aligned along the RNA genome that is sandwiched between two domains composed of conserved helix motifs. The viral RNA-dependent-RNA polymerase (vRdRp) must recognize the protein–RNA complex of the nucleocapsid and unveil the protected genomic RNA in order to initiate viral RNA synthesis. In addition, vRdRp must continuously translocate along the protein–RNA complex during elongation in viral RNA synthesis. This unique mechanism of viral RNA synthesis suggests that the nucleocapsid may play a regulatory role during NSV replication.
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Keywords:
negative strand RNA virus; nucleocapsid; viral RNA-dependent RNA polymerase; cofactor; cross subunit interactions; capsid protein motif; 5H+3H
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MDPI and ACS Style
Luo, M.; Terrell, J.R.; Mcmanus, S.A. Nucleocapsid Structure of Negative Strand RNA Virus. Viruses 2020, 12, 835. https://doi.org/10.3390/v12080835
AMA Style
Luo M, Terrell JR, Mcmanus SA. Nucleocapsid Structure of Negative Strand RNA Virus. Viruses. 2020; 12(8):835. https://doi.org/10.3390/v12080835
Chicago/Turabian StyleLuo, Ming, James R. Terrell, and Shelby A. Mcmanus. 2020. "Nucleocapsid Structure of Negative Strand RNA Virus" Viruses 12, no. 8: 835. https://doi.org/10.3390/v12080835
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