Next Article in Journal
Purinergic Receptors: Elucidating the Role of these Immune Mediators in HIV-1 Fusion
Next Article in Special Issue
Virus-Like Particle-Mediated Vaccination against Interleukin-13 May Harbour General Anti-Allergic Potential beyond Atopic Dermatitis
Previous Article in Journal
Porcine Circovirus 2 Induction of ROS Is Responsible for Mitophagy in PK-15 Cells via Activation of Drp1 Phosphorylation
Previous Article in Special Issue
Recent Advances in the Use of Plant Virus-Like Particles as Vaccines
Article

Immunization of Cats against Fel d 1 Results in Reduced Allergic Symptoms of Owners

1
Department of Dermatology, Zurich University Hospital, Wagistrasse 12, 8952 Schlieren/Zurich, Switzerland
2
HypoPet AG, Moussonstrasse 2, 8091 Zurich, Switzerland
3
Clinical Trials Center Zurich, University Hospital Zurich, Moussonstrasse 2, 8044 Zurich, Switzerland
4
vetderm.ch, Ennetseeklink für Kleintiere, Rothusstrasse 2, 6331 Hünenberg, Switzerland
5
dermaVet, Tierklinik Aarau West AG, Muhenstrasse 56, 5036 Oberentfelden, Switzerland
6
Graf Biostatistics, Amelenweg 5, 8400 Winterthur, Switzerland
7
Benchmark Animal Health, Benchmark Holdings Plc, 8 Smithy Wood Dr, Sheffield S35 1QN, UK
8
Director Research and Education, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, Switzerland
9
Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland
10
Department of Immunology, Inselspital, University of Bern, Salihaus 2, 3007 Bern, Switzerland
11
Jenner Institute, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7BN, UK
*
Author to whom correspondence should be addressed.
Viruses 2020, 12(3), 288; https://doi.org/10.3390/v12030288
Received: 28 January 2020 / Revised: 20 February 2020 / Accepted: 26 February 2020 / Published: 6 March 2020
(This article belongs to the Special Issue Virus-Like Particle Vaccines)
An innovative approach was tested to treat cat allergy in humans by vaccinating cats with Fel-CuMV (HypoCatTM), a vaccine against the major cat allergen Fel d 1 based on virus-like particles derived from cucumber mosaic virus (CuMV-VLPs). Upon vaccination, cats develop neutralizing antibodies against the allergen Fel d 1, which reduces the level of reactive allergen, thus lowering the symptoms or even preventing allergic reactions in humans. The combined methodological field study included ten cat-allergic participants who lived together with their cats (n = 13), that were immunized with Fel-CuMV. The aim was to determine methods for measuring a change in allergic symptoms. A home-based provocation test (petting time and organ specific symptom score (OSSS)) and a general weekly (or monthly) symptom score (G(W)SS) were used to assess changes in allergic symptoms. The petting time until a pre-defined level of allergic symptoms was reached increased already early after vaccination of the cats and was apparent over the course of the study. In addition, the OSSS after provocation and G(W)SS recorded a persistent reduction in symptoms over the study period and could serve for long-term assessment. Hence, the immunization of cats with HypoCatTM (Fel-CuMV) may have a positive impact on the cat allergy of the owner, and changes could be assessed by the provocation test as well as G(W)SS. View Full-Text
Keywords: cat allergy; vaccination; Fel d 1; HypoCat™; virus-like particle cat allergy; vaccination; Fel d 1; HypoCat™; virus-like particle
Show Figures

Figure 1

MDPI and ACS Style

Thoms, F.; Haas, S.; Erhart, A.; Nett, C.S.; Rüfenacht, S.; Graf, N.; Strods, A.; Patil, G.; Leenadevi, T.; Fontaine, M.C.; Toon, L.A.; Jennings, G.T.; Senti, G.; Kündig, T.M.; Bachmann, M.F. Immunization of Cats against Fel d 1 Results in Reduced Allergic Symptoms of Owners. Viruses 2020, 12, 288. https://doi.org/10.3390/v12030288

AMA Style

Thoms F, Haas S, Erhart A, Nett CS, Rüfenacht S, Graf N, Strods A, Patil G, Leenadevi T, Fontaine MC, Toon LA, Jennings GT, Senti G, Kündig TM, Bachmann MF. Immunization of Cats against Fel d 1 Results in Reduced Allergic Symptoms of Owners. Viruses. 2020; 12(3):288. https://doi.org/10.3390/v12030288

Chicago/Turabian Style

Thoms, Franziska, Stefanie Haas, Aline Erhart, Claudia S. Nett, Silvia Rüfenacht, Nicole Graf, Arnis Strods, Gauravraj Patil, Thonur Leenadevi, Michael C. Fontaine, Lindsey A. Toon, Gary T. Jennings, Gabriela Senti, Thomas M. Kündig, and Martin F. Bachmann 2020. "Immunization of Cats against Fel d 1 Results in Reduced Allergic Symptoms of Owners" Viruses 12, no. 3: 288. https://doi.org/10.3390/v12030288

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop