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Virus-Like Particle-Mediated Vaccination against Interleukin-13 May Harbour General Anti-Allergic Potential beyond Atopic Dermatitis

Department of Molecular and Clinical Medicine, University of Dundee, Medical School, Ninewells Hospital, Jacquie Woods Centre, Ninewells Drive, Dundee DD1 9SY, UK
Authors to whom correspondence should be addressed.
Viruses 2020, 12(4), 438;
Received: 6 March 2020 / Revised: 31 March 2020 / Accepted: 9 April 2020 / Published: 13 April 2020
(This article belongs to the Special Issue Virus-Like Particle Vaccines)
Virus-like particle (VLP)-based anti-infective prophylactic vaccination has been established in clinical use. Although validated in proof-of-concept clinical trials in humans, no VLP-based therapeutic vaccination against self-proteins to modulate chronic disease has yet been licensed. The present review summarises recent scientific advances, identifying interleukin-13 as an excellent candidate to validate the concept of anti-cytokine vaccination. Based on numerous clinical studies, long-term elimination of IL-13 is not expected to trigger target-related serious adverse effects and is likely to be safer than combined targeting of IL-4/IL-13. Furthermore, recently published results from large-scale trials confirm that elimination of IL-13 is highly effective in atopic dermatitis, an exceedingly common condition, as well as eosinophilic esophagitis. The distinctly different mode of action of a polyclonal vaccine response is discussed in detail, suggesting that anti-IL-13 vaccination has the potential of outperforming monoclonal antibody-based approaches. Finally, recent data have identified a subset of follicular T helper cells dependent on IL-13 which selectively trigger massive IgE accumulation in response to anaphylactoid allergens. Thus, prophylactic IL-13 vaccination may have broad application in a number of allergic conditions. View Full-Text
Keywords: VLP; IL-13; interleukin-13; vaccine; Tfh cells VLP; IL-13; interleukin-13; vaccine; Tfh cells
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Foerster, J.; Molęda, A. Virus-Like Particle-Mediated Vaccination against Interleukin-13 May Harbour General Anti-Allergic Potential beyond Atopic Dermatitis. Viruses 2020, 12, 438.

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