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Open AccessArticle

Antibiotic Minocycline Prevents Respiratory Syncytial Virus Infection

Center for NanoBiotechnology Research, Life Science Building, Harris way, Montgomery, AL 36104, USA
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Viruses 2019, 11(8), 739; https://doi.org/10.3390/v11080739
Received: 10 July 2019 / Revised: 5 August 2019 / Accepted: 7 August 2019 / Published: 11 August 2019
(This article belongs to the Section Antivirals & Vaccines)
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PDF [1403 KB, uploaded 11 August 2019]
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Abstract

Treatment drugs, besides their specific activity, often have multiple effects on the body. The undesired effect of the drug may be repurposed as therapeutics, saving significant investigative time and effort. Minocycline has anti-cancer, anti-oxidant, anti-inflammatory, and anti-apoptotic properties. Presently, minocycline is also known to show anti-viral activity against Influenza virus, Japanese encephalitis virus, Simian immunodeficiency virus, Human immunodeficiency virus and West Nile virus. Here, we investigate the effect of minocycline on Respiratory syncytial virus (RSV), a common respiratory virus that causes severe mortality and morbidity in infants, children, and older adult populations. Currently, there is no effective vaccine or treatment for RSV infection; hence, there is a critical need for alternative and effective drug choices. Our study shows that minocycline reduces the RSV-mediated cytopathic effect and prevents RSV infection. This is the first study demonstrating the anti-viral activity of minocycline against RSV. View Full-Text
Keywords: pneumonia; bronchiolitis; antiviral; antibiotics; minocycline; RSV; Parkin-Ubiquitin pathway; respiratory diseases; neurodegenerative diseases pneumonia; bronchiolitis; antiviral; antibiotics; minocycline; RSV; Parkin-Ubiquitin pathway; respiratory diseases; neurodegenerative diseases
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Bawage, S.S.; Tiwari, P.M.; Pillai, S.; Dennis, V.A.; Singh, S.R. Antibiotic Minocycline Prevents Respiratory Syncytial Virus Infection. Viruses 2019, 11, 739.

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