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Haemostatic Changes in Five Patients Infected with Ebola Virus

1
Chemical Biological & Radiological Division, Dstl, Porton Down SP4 0JQ, UK
2
Royal Centre for Defence Medicine, Birmingham Research Park, Birmingham B15 2SQ, UK
3
Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK
4
St Thomas’ Hospital Thrombosis & Haemophilia Centre & Thrombosis and Vascular Biology Group, London SE1 7EH, UK
*
Author to whom correspondence should be addressed.
Viruses 2019, 11(7), 647; https://doi.org/10.3390/v11070647
Received: 11 June 2019 / Revised: 3 July 2019 / Accepted: 11 July 2019 / Published: 15 July 2019
(This article belongs to the Special Issue Medical Advances in Viral Hemorrhagic Fever Research)
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Abstract

Knowledge on haemostatic changes in humans infected with Ebola virus is limited due to safety concerns and access to patient samples. Ethical approval was obtained to collect plasma samples from patients in Sierra Leone infected with Ebola virus over time and samples were analysed for clotting time, fibrinogen, and D-dimer levels. Plasma from healthy volunteers was also collected by two methods to determine effect of centrifugation on test results as blood collected in Sierra Leone was not centrifuged. Collecting plasma without centrifugation only affected D-dimer values. Patients with Ebola virus disease had higher PT and APTT and D-dimer values than healthy humans with plasma collected in the same manner. Fibrinogen levels in patients with Ebola virus disease were normal or lower than values measured in healthy people. Clotting times and D-dimer levels were elevated during infection with Ebola virus but return to normal over time in patients that survived and therefore could be considered prognostic. Informative data can be obtained from plasma collected without centrifugation which could improve patient monitoring in hazardous environments. View Full-Text
Keywords: Ebola virus; haemostasis; clotting; D-dimers; fibrinogen; PT; APTT Ebola virus; haemostasis; clotting; D-dimers; fibrinogen; PT; APTT
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Smither, S.J.; O’Brien, L.M.; Eastaugh, L.; Woolley, T.; Lever, M.; Fletcher, T.; Parmar, K.; Hunt, B.J.; Watts, S.; Kirkman, E. Haemostatic Changes in Five Patients Infected with Ebola Virus. Viruses 2019, 11, 647.

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