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Biological Function and Application of Picornaviral 2B Protein: A New Target for Antiviral Drug Development

1
School of Public Health, Nanchang University, Nanchang 330006, China
2
Department of Medical Microbiology, School of Medicine, Nanchang University, Nanchang 330006, China
3
Jiangxi Medical College, Nanchang University, Nanchang 330006, China
*
Author to whom correspondence should be addressed.
Viruses 2019, 11(6), 510; https://doi.org/10.3390/v11060510
Received: 13 May 2019 / Revised: 31 May 2019 / Accepted: 2 June 2019 / Published: 4 June 2019
(This article belongs to the Special Issue Human Picornaviruses)
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PDF [14888 KB, uploaded 4 June 2019]
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Abstract

Picornaviruses are associated with acute and chronic diseases. The clinical manifestations of infections are often mild, but infections may also lead to respiratory symptoms, gastroenteritis, myocarditis, meningitis, hepatitis, and poliomyelitis, with serious impacts on human health and economic losses in animal husbandry. Thus far, research on picornaviruses has mainly focused on structural proteins such as VP1, whereas the non-structural protein 2B, which plays vital roles in the life cycle of the viruses and exhibits a viroporin or viroporin-like activity, has been overlooked. Viroporins are viral proteins containing at least one amphipathic α-helical structure, which oligomerizes to form transmembrane hydrophilic pores. In this review, we mainly summarize recent research data on the viroporin or viroporin-like activity of 2B proteins, which affects the biological function of the membrane, regulates cell death, and affects the host immune response. Considering these mechanisms, the potential application of the 2B protein as a candidate target for antiviral drug development is discussed, along with research challenges and prospects toward realizing a novel treatment strategy for picornavirus infections. View Full-Text
Keywords: picornavirus; 2B protein; viroporin; drug development picornavirus; 2B protein; viroporin; drug development
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Li, Z.; Zou, Z.; Jiang, Z.; Huang, X.; Liu, Q. Biological Function and Application of Picornaviral 2B Protein: A New Target for Antiviral Drug Development. Viruses 2019, 11, 510.

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