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Porcine Dendritic Cells and Viruses: An Update

1
Istituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy
2
The Pirbright Institute, Ash Road, Pirbright GU24 0NF, UK
3
School of Veterinary Medicine, University of Surrey, Guildford GU2 7AL, UK
*
Author to whom correspondence should be addressed.
Viruses 2019, 11(5), 445; https://doi.org/10.3390/v11050445
Received: 29 April 2019 / Revised: 12 May 2019 / Accepted: 14 May 2019 / Published: 16 May 2019
(This article belongs to the Special Issue Porcine Viruses 2019)
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Abstract

Several viral infections of swine are responsible for major economic losses and represent a threat to the swine industry worldwide. New tools are needed to prevent and control endemic, emerging, and re-emerging viral diseases. Dendritic cells (DC) play a central role in linking the innate and adaptive arms of the immune system, so knowledge regarding their interaction with pathogens is necessary to understand the mechanisms underlying diseases pathogenesis and protection. In the first part of this review, we provide an update on the heterogeneous cell subsets that comprise the porcine DC family. In the second part of this review, we provide an overview of how three viruses, affecting pork production at a global level, African swine fever virus (ASFV), classical swine fever virus (CSFV), and porcine circovirus 2 (PCV2), modulate DC function. View Full-Text
Keywords: pig; dendritic cells; ASFV; CSFV; PCV2 pig; dendritic cells; ASFV; CSFV; PCV2
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Franzoni, G.; Graham, S.P.; Dei Giudici, S.; Oggiano, A. Porcine Dendritic Cells and Viruses: An Update. Viruses 2019, 11, 445.

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