Next Article in Journal
Interaction between Two Iridovirus Core Proteins and Their Effects on Ranavirus (RGV) Replication in Cells from Different Species
Next Article in Special Issue
Parvovirus B19 Uncoating Occurs in the Cytoplasm without Capsid Disassembly and It Is Facilitated by Depletion of Capsid-Associated Divalent Cations
Previous Article in Journal
Potential Application of TALENs against Murine Cytomegalovirus Latent Infections
Previous Article in Special Issue
Adeno-Associated Virus VP1u Exhibits Protease Activity
Open AccessReview

Immune System Stimulation by Oncolytic Rodent Protoparvoviruses

German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Author to whom correspondence should be addressed.
Viruses 2019, 11(5), 415;
Received: 18 April 2019 / Revised: 29 April 2019 / Accepted: 2 May 2019 / Published: 4 May 2019
(This article belongs to the Special Issue New Insights into Parvovirus Research)
Rodent protoparvoviruses (PVs), parvovirus H-1 (H-1PV) in particular, are naturally endowed with oncolytic properties. While being historically described as agents that selectively replicate in and kill cancer cells, recent yet growing evidence demonstrates that these viruses are able to reverse tumor-driven immune suppression through induction of immunogenic tumor cell death, and the establishment of antitumorigenic, proinflammatory milieu within the tumor microenvironment. This review summarizes the most important preclinical proofs of the interplay and the cooperation between PVs and the host immune system. The molecular mechanisms of PV-induced immunostimulation are also discussed. Furthermore, initial encouraging in-human observations from clinical trials and compassionate virus uses are presented, and speak in favor of further H-1PV clinical development as partner drug in combined immunotherapeutic protocols. View Full-Text
Keywords: rodent protoparvoviruses; oncolytic activity; tumor microenvironment; immunomodulation; preclinical; clinical trials rodent protoparvoviruses; oncolytic activity; tumor microenvironment; immunomodulation; preclinical; clinical trials
Show Figures

Figure 1

MDPI and ACS Style

Angelova, A.; Rommelaere, J. Immune System Stimulation by Oncolytic Rodent Protoparvoviruses. Viruses 2019, 11, 415.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop