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Immune System Stimulation by Oncolytic Rodent Protoparvoviruses

German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
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Viruses 2019, 11(5), 415; https://doi.org/10.3390/v11050415
Received: 18 April 2019 / Revised: 29 April 2019 / Accepted: 2 May 2019 / Published: 4 May 2019
(This article belongs to the Special Issue New Insights into Parvovirus Research)
Rodent protoparvoviruses (PVs), parvovirus H-1 (H-1PV) in particular, are naturally endowed with oncolytic properties. While being historically described as agents that selectively replicate in and kill cancer cells, recent yet growing evidence demonstrates that these viruses are able to reverse tumor-driven immune suppression through induction of immunogenic tumor cell death, and the establishment of antitumorigenic, proinflammatory milieu within the tumor microenvironment. This review summarizes the most important preclinical proofs of the interplay and the cooperation between PVs and the host immune system. The molecular mechanisms of PV-induced immunostimulation are also discussed. Furthermore, initial encouraging in-human observations from clinical trials and compassionate virus uses are presented, and speak in favor of further H-1PV clinical development as partner drug in combined immunotherapeutic protocols. View Full-Text
Keywords: rodent protoparvoviruses; oncolytic activity; tumor microenvironment; immunomodulation; preclinical; clinical trials rodent protoparvoviruses; oncolytic activity; tumor microenvironment; immunomodulation; preclinical; clinical trials
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Angelova, A.; Rommelaere, J. Immune System Stimulation by Oncolytic Rodent Protoparvoviruses. Viruses 2019, 11, 415.

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