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Viruses 2018, 10(7), 350; https://doi.org/10.3390/v10070350

Tick-Borne Encephalitis Virus: A Structural View

1
HiLIFE—Institute of Biotechnology, University of Helsinki, 00790 Helsinki, Finland
2
Faculty of Biological and Environmental Sciences, University of Helsinki, 00790 Helsinki, Finland
*
Author to whom correspondence should be addressed.
Received: 8 June 2018 / Revised: 25 June 2018 / Accepted: 27 June 2018 / Published: 28 June 2018
(This article belongs to the Special Issue Biology and Treatment of Tick-Borne Viral Pathogens)
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Abstract

Tick-borne encephalitis virus (TBEV) is a growing health concern. It causes a severe disease that can lead to permanent neurological complications or death and the incidence of TBEV infections is constantly rising. Our understanding of TBEV’s structure lags behind that of other flaviviruses, but has advanced recently with the publication of a high-resolution structure of the TBEV virion. The gaps in our knowledge include: aspects of receptor binding, replication and virus assembly. Furthermore, TBEV has mostly been studied in mammalian systems, even though the virus’ interaction with its tick hosts is a central part of its life cycle. Elucidating these aspects of TBEV biology are crucial for the development of TBEV antivirals, as well as the improvement of diagnostics. In this review, we summarise the current structural knowledge on TBEV, bringing attention to the current gaps in our understanding, and propose further research that is needed to truly understand the structural-functional relationship of the virus and its hosts. View Full-Text
Keywords: tick-borne encephalitis virus; TBEV; flavivirus structure; envelope protein; M protein; E protein; prM; nucleocapsid; virus assembly; maturation tick-borne encephalitis virus; TBEV; flavivirus structure; envelope protein; M protein; E protein; prM; nucleocapsid; virus assembly; maturation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Pulkkinen, L.I.A.; Butcher, S.J.; Anastasina, M. Tick-Borne Encephalitis Virus: A Structural View. Viruses 2018, 10, 350.

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