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Open AccessArticle

Alston Virus, a Novel Paramyxovirus Isolated from Bats Causes Upper Respiratory Tract Infection in Experimentally Challenged Ferrets

1
CSIRO Health and Biosecurity, Australian Animal Health Laboratory, Geelong 3220, Australia
2
Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore
*
Author to whom correspondence should be addressed.
Viruses 2018, 10(12), 675; https://doi.org/10.3390/v10120675
Received: 18 October 2018 / Revised: 14 November 2018 / Accepted: 15 November 2018 / Published: 28 November 2018
(This article belongs to the Special Issue Viruses and Bats 2019)
Multiple viruses with zoonotic potential have been isolated from bats globally. Here we describe the isolation and characterization of a novel paramyxovirus, Alston virus (AlsPV), isolated from urine collected from an Australian pteropid bat colony in Alstonville, New South Wales. Characterization of AlsPV by whole-genome sequencing and analyzing antigenic relatedness revealed it is a rubulavirus that is closely related to parainfluenza virus 5 (PIV5). Intranasal exposure of mice to AlsPV resulted in no clinical signs of disease, although viral RNA was detected in the olfactory bulbs of two mice at 21 days post exposure. Oronasal challenge of ferrets resulted in subclinical upper respiratory tract infection, viral shedding in respiratory secretions, and detection of viral antigen in the olfactory bulb of the brain. These results imply that AlsPV may be similar to PIV5 in its ability to infect multiple mammalian host species. This isolation of a novel paramyxovirus with the potential to transmit from bats to other mammalian species reinforces the importance of continued surveillance of bats as a source of emerging viruses. View Full-Text
Keywords: paramyxovirus; bat-borne; zoonoses paramyxovirus; bat-borne; zoonoses
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Johnson, R.I.; Tachedjian, M.; Rowe, B.; Clayton, B.A.; Layton, R.; Bergfeld, J.; Wang, L.-F.; Marsh, G.A. Alston Virus, a Novel Paramyxovirus Isolated from Bats Causes Upper Respiratory Tract Infection in Experimentally Challenged Ferrets. Viruses 2018, 10, 675.

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