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Viruses 2018, 10(1), 37; https://doi.org/10.3390/v10010037

Structural Insights in Multifunctional Papillomavirus Oncoproteins

Équipe Labellisée Ligue 2015, Department of Integrated Structural Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U1258/CNRS UMR 7104/Université de Strasbourg, 1 rue Laurent Fries, BP 10142, F-67404 Illkirch, France
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Received: 3 December 2017 / Revised: 10 January 2018 / Accepted: 11 January 2018 / Published: 15 January 2018
(This article belongs to the Special Issue Expert Views on HPV Infection)
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Abstract

Since their discovery in the mid-eighties, the main papillomavirus oncoproteins E6 and E7 have been recalcitrant to high-resolution structure analysis. However, in the last decade a wealth of three-dimensional information has been gained on both proteins whether free or complexed to host target proteins. Here, we first summarize the diverse activities of these small multifunctional oncoproteins. Next, we review the available structural data and the new insights they provide about the evolution of E6 and E7, their multiple interactions and their functional variability across human papillomavirus (HPV) species. View Full-Text
Keywords: papillomaviruses; oncoproteins; structure; X-ray; NMR; virus-host interactomics papillomaviruses; oncoproteins; structure; X-ray; NMR; virus-host interactomics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Suarez, I.; Trave, G. Structural Insights in Multifunctional Papillomavirus Oncoproteins. Viruses 2018, 10, 37.

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