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Viruses 2018, 10(1), 40;

CRISPR-Cas Targeting of Host Genes as an Antiviral Strategy

School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China
Institute of Health Inspection and Testing, Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China
School of Medicine (Shenzhen), Sun Yat-sen University, Guangzhou 510080, China
Author to whom correspondence should be addressed.
Received: 24 December 2017 / Revised: 12 January 2018 / Accepted: 14 January 2018 / Published: 16 January 2018
(This article belongs to the Special Issue Applications of CRISPR Technology in Virology 2018)
PDF [714 KB, uploaded 16 January 2018]


Currently, a new gene editing tool—the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) associated (Cas) system—is becoming a promising approach for genetic manipulation at the genomic level. This simple method, originating from the adaptive immune defense system in prokaryotes, has been developed and applied to antiviral research in humans. Based on the characteristics of virus-host interactions and the basic rules of nucleic acid cleavage or gene activation of the CRISPR-Cas system, it can be used to target both the virus genome and host factors to clear viral reservoirs and prohibit virus infection or replication. Here, we summarize recent progress of the CRISPR-Cas technology in editing host genes as an antiviral strategy. View Full-Text
Keywords: gene targeting; CRISPR-Cas; host genes; virus; antiviral strategy gene targeting; CRISPR-Cas; host genes; virus; antiviral strategy

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Chen, S.; Yu, X.; Guo, D. CRISPR-Cas Targeting of Host Genes as an Antiviral Strategy. Viruses 2018, 10, 40.

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