Evaluation of the Antimicrobial Activity of Different Antibiotics Enhanced with Silver-Doped Hydroxyapatite Thin Films
Abstract
:1. Introduction
2. Materials and Methods
2.1. Tetracycline or Ciprofloxacin Embedded in Silver-Doped Hydroxyapatite Thin Films
2.2. Characterization Methods
2.3. Preliminary Observations of Antimicrobial Properties of the HAp, T-HAp, C-HAp, Ag:HAp, T-Ag:HAp and C-Ag:HAp Tetracycline (T) and Ciprofloxacin (C)
2.4. Antimicrobial Activity of the HAp, T-HAp, C-HAp, Ag:HAp, T-Ag:HAp and C-Ag:HAp, Tetracycline (T) and Ciprofloxacin (C)
2.5. Statistical Analysis
3. Results and Discussion
4. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Bacterial Strains | Thin Films Samples | Mean Zone of Inhibition (mm) |
---|---|---|
E. coli ATCC 25922 | Si (control) | 0 |
HAp | 0 | |
T-HAp | 17 ± 0.3 | |
C-HAp | 19 ± 0.5 | |
Ag:HAp | 23 ± 0.6 | |
T-Ag:HAp | 25 ± 0.7 | |
C-Ag:HAp | 28 ± 0.2 | |
T | 20 ± 0.4 | |
C | 26 ± 0.3 | |
S. aureus 0364 | Si (control) | 0 |
HAp | 0 | |
T-HAp | 26 ± 0.5 | |
C-HAp | 24 ± 0.5 | |
Ag:HAp | 30 ± 0.6 | |
T-Ag:HAp | 40 ± 0.7 | |
C-Ag:HAp | 35 ± 0.4 | |
T | 33 ± 0.5 | |
C | 31 ± 0.7 |
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Predoi, D.; Popa, C.L.; Chapon, P.; Groza, A.; Iconaru, S.L. Evaluation of the Antimicrobial Activity of Different Antibiotics Enhanced with Silver-Doped Hydroxyapatite Thin Films. Materials 2016, 9, 778. https://doi.org/10.3390/ma9090778
Predoi D, Popa CL, Chapon P, Groza A, Iconaru SL. Evaluation of the Antimicrobial Activity of Different Antibiotics Enhanced with Silver-Doped Hydroxyapatite Thin Films. Materials. 2016; 9(9):778. https://doi.org/10.3390/ma9090778
Chicago/Turabian StylePredoi, Daniela, Cristina Liana Popa, Patrick Chapon, Andreea Groza, and Simona Liliana Iconaru. 2016. "Evaluation of the Antimicrobial Activity of Different Antibiotics Enhanced with Silver-Doped Hydroxyapatite Thin Films" Materials 9, no. 9: 778. https://doi.org/10.3390/ma9090778