Synthesis and In Vitro Activity Assessment of Novel Silicon Oxycarbide-Based Bioactive Glasses
1
FB Material-und Geowissenschaften, Technische Universität Darmstadt, Jovanka-Bontschits-Strasse 2, Darmstadt D-64287, Germany
2
Department of Materials Science and Engineering, Institute of Biomaterials, University of Erlangen-Nuremberg, Cauerstrasse 6, Erlangen D-91058, Germany
3
Institute for Inorganic Chemistry, University of Cologne, Greinstrasse 6, Köln D-50939, Germany
*
Authors to whom correspondence should be addressed.
Academic Editor: Jérôme Chevalier
Materials 2016, 9(12), 959; https://doi.org/10.3390/ma9120959
Received: 18 October 2016 / Revised: 12 November 2016 / Accepted: 15 November 2016 / Published: 24 November 2016
(This article belongs to the Special Issue Bioceramics 2016)
Novel bioactive glasses based on a Ca- and Mg-modified silicon oxycarbide (SiCaMgOC) were prepared from a polymeric single-source precursor, and their in vitro activity towards hydroxyapatite mineralization was investigated upon incubating the samples in simulated body fluid (SBF) at 37 °C. The as-prepared materials exhibit an outstanding resistance against devitrification processes and maintain their amorphous nature even after exposure to 1300 °C. The X-ray diffraction (XRD) analysis of the SiCaMgOC samples after the SBF test showed characteristic reflections of apatite after only three days, indicating a promising bioactivity. The release kinetics of the Ca2+ and Mg2+ and the adsorption of H+ after immersion of SiCaMgOC in simulated body fluid for different soaking times were analyzed via optical emission spectroscopy. The results show that the mechanism of formation of apatite on the surface of the SiCaMgOC powders is similar to that observed for standard (silicate) bioactive glasses. A preliminary cytotoxicity investigation of the SiOC-based bioactive glasses was performed in the presence of mouse embryonic fibroblasts (MEF) as well as human embryonic kidney cells (HEK-293). Due to their excellent high-temperature crystallization resistance in addition to bioactivity, the Ca- and Mg-modified SiOC glasses presented here might have high potential in applications related to bone repair and regeneration.
View Full-Text
Keywords:
SiOC; Ca- and Mg-modified silicon oxycarbide; polymeric single source precursors; bioactive glass; bioactivity; cytotoxicity
▼
Show Figures
Figure 1
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Gonzalo-Juan, I.; Detsch, R.; Mathur, S.; Ionescu, E.; Boccaccini, A.R.; Riedel, R. Synthesis and In Vitro Activity Assessment of Novel Silicon Oxycarbide-Based Bioactive Glasses. Materials 2016, 9, 959. https://doi.org/10.3390/ma9120959
AMA Style
Gonzalo-Juan I, Detsch R, Mathur S, Ionescu E, Boccaccini AR, Riedel R. Synthesis and In Vitro Activity Assessment of Novel Silicon Oxycarbide-Based Bioactive Glasses. Materials. 2016; 9(12):959. https://doi.org/10.3390/ma9120959
Chicago/Turabian StyleGonzalo-Juan, Isabel; Detsch, Rainer; Mathur, Sanjay; Ionescu, Emanuel; Boccaccini, Aldo R.; Riedel, Ralf. 2016. "Synthesis and In Vitro Activity Assessment of Novel Silicon Oxycarbide-Based Bioactive Glasses" Materials 9, no. 12: 959. https://doi.org/10.3390/ma9120959
Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
Search more from Scilit
