Effect of Winemaking on the Composition of Red Wine as a Source of Polyphenols for Anti-Infective Biomaterials
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Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, V.le Taramelli 12, Pavia 27100, Italy
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Molecular Medicine Department, Center for Health Technologies (CHT), UdR INSTM, University of Pavia, Viale Taramelli 3/b, Pavia 27100, Italy
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Research Group on Community Nutrition and Oxidative Stress and CIBEROBN (Physiopathology of Obesity and Nutrition), University of Balearic Islands, Palma de Mallorca, Balearic Islands E-07122, Spain
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Department of Pharmaceutical and Toxicology Chemistry, University of Napoli Federico II, Via D. Montesano 49, Napoli 80131, Italy
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Department of Occupational Medicine, Toxicology and Environmental Risks, S. Maugeri Foundation, IRCCS, Via S. Boezio 28, Pavia 27100, Italy
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Research Unit on Implant Infections, Rizzoli Orthopaedic Institute, via di Barbiano 1/10, Bologna 40136, Italy
7
Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, via San Giacomo 14, Bologna 40126, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: Maryam Tabrizian
Materials 2016, 9(5), 316; https://doi.org/10.3390/ma9050316
Received: 22 February 2016
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Revised: 29 March 2016
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Accepted: 20 April 2016
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Published: 27 April 2016
(This article belongs to the Special Issue Anti-Infective Materials in Medicine and Technology)
Biomaterials releasing bactericides have currently become tools for thwarting medical device-associated infections. The ideal anti-infective biomaterial must counteract infection while safeguarding eukaryotic cell integrity. Red wine is a widely consumed beverage to which many biological properties are ascribed, including protective effects against oral infections and related bone (osteoarthritis, osteomyelitis, periprosthetic joint infections) and cardiovascular diseases. In this study, fifteen red wine samples derived from grapes native to the Oltrepò Pavese region (Italy), obtained from the winemaking processes of “Bonarda dell’Oltrepò Pavese” red wine, were analyzed alongside three samples obtained from marc pressing. Total polyphenol and monomeric anthocyanin contents were determined and metabolite profiling was conducted by means of a chromatographic analysis. Antibacterial activity of wine samples was evaluated against Streptococcus mutans, responsible for dental caries, Streptococcus salivarius, and Streptococcus pyogenes, two oral bacterial pathogens. Results highlighted the winemaking stages in which samples exhibit the highest content of polyphenols and the greatest antibacterial activity. Considering the global need for new weapons against bacterial infections and alternatives to conventional antibiotics, as well as the favorable bioactivities of polyphenols, results point to red wine as a source of antibacterial substances for developing new anti-infective biomaterials and coatings for biomedical devices.
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Keywords:
red wine; winemaking process; metabolite profiling; polyphenols; anti-infective biomaterials
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Di Lorenzo, A.; Bloise, N.; Meneghini, S.; Sureda, A.; Tenore, G.C.; Visai, L.; Arciola, C.R.; Daglia, M. Effect of Winemaking on the Composition of Red Wine as a Source of Polyphenols for Anti-Infective Biomaterials. Materials 2016, 9, 316. https://doi.org/10.3390/ma9050316
AMA Style
Di Lorenzo A, Bloise N, Meneghini S, Sureda A, Tenore GC, Visai L, Arciola CR, Daglia M. Effect of Winemaking on the Composition of Red Wine as a Source of Polyphenols for Anti-Infective Biomaterials. Materials. 2016; 9(5):316. https://doi.org/10.3390/ma9050316
Chicago/Turabian StyleDi Lorenzo, Arianna, Nora Bloise, Silvia Meneghini, Antoni Sureda, Gian C. Tenore, Livia Visai, Carla R. Arciola, and Maria Daglia. 2016. "Effect of Winemaking on the Composition of Red Wine as a Source of Polyphenols for Anti-Infective Biomaterials" Materials 9, no. 5: 316. https://doi.org/10.3390/ma9050316
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